含荧光基团透明质酸衍生物的合成及其荧光性能  

Synthesis and Fluorescence Properties of Hyaluronic Acid Derivatives Containing Fluorescent Groups

作　　者：周维杰[1] 席海涛[1] 孙小强[1] 

机构地区：[1]常州大学石油化工学院,江苏常州213164

出　　处：《常州大学学报（自然科学版）》2013年第4期57-60,共4页Journal of Changzhou University：Natural Science Edition

基　　金：国家自然科学基金项目资助(20872051)

摘　　要：以透明质酸钠和7-羟基-4-甲基香豆素为原料,合成了具有荧光性能的透明质酸衍生物。通过模拟人体的生理环境,研究了浓度、pH和温度变化对透明质酸衍生物荧光性能的影响。结果表明,透明质酸衍生物荧光强度随浓度的增大而增强,随pH变化其荧光强度变化趋势不明显,较为稳定,随温度的变化其荧光强度基本保持稳定。为以后探索具有药物载体透明质酸在机体内的作用机理及其靶向作用提供良好的实验基础。The hyaluronic acid derivatives with fluorescence performance were synthesized from sodium hyaluronate and 7-hydroxy-4-methyl coumarin.Then the influences of the concentration,pH and temperature on fluorescence intensity of hyaluronic acid derivatives were studied under the human body physiological environment.The results showed that fluorescence strength of the hyaluronic acid derivatives enhanced with intensity increased,kept stable and had an unobvious change as pH changed.Also the fluorescence strength performed a basical stability while temperature varied.These provided good experimental bases for the mechanism of action of hyaluronic acid as a drug carrier in human body as well as its targeting effect in the future.

关 键 词：透明质酸 7-羟基-4-甲基香豆素 荧光性能 

分 类 号：TQ201[化学工程—有机化工]