Synthesis, characterization,thermal behavior,and antifungal activity of La(Ⅲ) complexes with cinnamates and 4-methoxyphenylacetate  

作　　者：Alberto Aragón-Muriel Dorian Polo-Cerón 

机构地区：[1]Departamento de Química,Universidad del Valle, Calle 13 No 100-00 Cali,Colombia 76001000

出　　处：《Journal of Rare Earths》2013年第11期1106-1113,共8页稀土学报（英文版）

摘　　要：In this study a series of trivalent lanthanum complexes with 4-（R）-cinnamate （4-Rcinn, R=H（1）, MeO（2）, Cl（3）） and 4-methoxyphenylacetate ligands （4） were prepared and their antifungal activity against Candida albicans, Aspergillus niger and Trichophyton mentagrophytes were examined. Compounds 1-4 were synthesized by a metathesis reaction and fully characterized by elemental analysis, IR, 1H and 13C NMR spectroscopy, fluorescence spectra, thermogravimetry （TG）, derivative thermogravimetry （DTG）, differential scanning calorimetry （DSC） and X-ray diffraction powder patterns. In emission studies, it was observed that lu-minescence intensity was enhanced in the presence of lanthanide ion. The results of X-ray diffraction patterns indicated that all com-plexes studied exhibited crystalline structure. Thermal behavior by TG, DTG, and DSC studies permitted to estimating the hydration degree of the compounds and showed the formation of decomposition products like lanthanum oxide. Determined by antifungal stud-ies, lanthanum complexes 1-4 demonstrated antifungal activity toward all pathogenic fungal strains tested. Compounds 2 and 4 showed significant growth inhibition for A. niger and C. albicans, respectively.In this study a series of trivalent lanthanum complexes with 4-（R）-cinnamate （4-Rcinn, R=H（1）, MeO（2）, Cl（3）） and 4-methoxyphenylacetate ligands （4） were prepared and their antifungal activity against Candida albicans, Aspergillus niger and Trichophyton mentagrophytes were examined. Compounds 1-4 were synthesized by a metathesis reaction and fully characterized by elemental analysis, IR, 1H and 13C NMR spectroscopy, fluorescence spectra, thermogravimetry （TG）, derivative thermogravimetry （DTG）, differential scanning calorimetry （DSC） and X-ray diffraction powder patterns. In emission studies, it was observed that lu-minescence intensity was enhanced in the presence of lanthanide ion. The results of X-ray diffraction patterns indicated that all com-plexes studied exhibited crystalline structure. Thermal behavior by TG, DTG, and DSC studies permitted to estimating the hydration degree of the compounds and showed the formation of decomposition products like lanthanum oxide. Determined by antifungal stud-ies, lanthanum complexes 1-4 demonstrated antifungal activity toward all pathogenic fungal strains tested. Compounds 2 and 4 showed significant growth inhibition for A. niger and C. albicans, respectively.

关 键 词：antifungal activity La（III） complexes CINNAMATES 4-methoxyphenylacetate infrared spectra excitation emission TG-DTG-DSC Candida albicans Aspergillus niger Trichophyton mentagrophytes rare earths 

分 类 号：R285[医药卫生—中药学]