巴戟天不同炮制品补肾壮阳作用的比较研究  

Comparative study on kidney tonifying and Yang supporting effects of different processed products of Morinda officinalis

作　　者：崔妮[1] 史辑[1] 贾天柱[1,2,3] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600 [2]国家中医药管理局中药炮制原理重点研究室,辽宁大连116600 [3]辽宁省中药炮制工程技术研究中心,辽宁大连116600

出　　处：《中国中药杂志》2013年第22期3898-3901,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金青年基金项目(81001635);国家中医药管理局行业专项(201107007)

摘　　要：为了比较巴戟天不同炮制品补肾壮阳药理作用,采用腺嘌呤灌胃给药的方法建立小鼠肾阳虚模型,分别给予巴戟天、巴戟肉、盐巴戟、制巴戟4种炮制品,以桂附地黄丸为对照,以小鼠体征、体重、睾丸系数、精囊腺系数、血清睾酮(T)、血清皮质醇(cortisol)、血清肌酐(Cr)、组织病理学检查等为评价指标。结果表明,各炮制品均可以改善肾阳虚小鼠的症状,其中盐巴戟组治疗效果最为显著,其次是制巴戟、巴戟肉、巴戟天。该实验结果可为阐明巴戟天炮制原理和补肾壮阳机制提供实验数据。To compare the pharmacological effects for tonifying kidney and supporting Yang of different processed products of Morinda officinalis. The oral administration of adenine was performed to establish the kidney-Yang deficiency mice model. Four differ- ent processed products, namely M. officinalis, morinda pulp, salt-steamed M. officinalis and licorice-processed M. officinalis, were administered, with Guifu Dihuang pills as the control drug, and mice signs, weight, testicular coefficient, seminal vesicle coefficient, serum testosterone, serum cortisol and serum crcatinine as evaluation indexes. The results showed that all of the four processed prod- ucts of M. officinalis could improve the symptoms of the kidney-Yang deficient mice. Among them, salt-steamed M. officinalis had the most significant effect, which was followed by licorice-processed M. officinalis, morinda pulp and M. officinalis.

关 键 词：巴戟天 炮制 腺嘌呤 肾阳虚 补肾助阳 

分 类 号：R285[医药卫生—中药学]