微流控芯片技术在药物活性研究中的应用进展  

Applications of microfluidic chip in drug activity research

作　　者：蔡亚梅[1] 洪战英[1] 朱臻宇[1] 柴逸峰[1] 

机构地区：[1]第二军医大学药学院药物分析学教研室,上海200433

出　　处：《药物分析杂志》2013年第11期2013-2018,共6页Chinese Journal of Pharmaceutical Analysis

基　　金：国家自然科学基金(No.81273472);上海市科学技术委员会课题(No.12401900802)

摘　　要：微流控芯片技术作为近年来最前沿的分析技术之一,具有微型化、高通量、高内涵、多功能集成等特点,在药物活性研究领域中得到广泛的关注。本文简单介绍了微流控芯片的原理和相关技术,从细胞、"器官"、模式生物3个层面综述微流控芯片技术在药物活性研究中的应用进展,并展望了微流控芯片的发展前景。Microfluidic chip, which is one of the most striking analytical technologies in recent years, has many ben- efits including miniaturizing, high -throughput, high -content, and multi -functional intergration. It has received widespread attention in the field of drug activity research. This paper briefly introduced the general concept of mi- erofluidic chip and related technologies. The applications of microfluidic chips in drug activity research were re- viewed from aspects of cells, organs and organisms. At last, the development of microfluidic chips was prospected.

关 键 词：微流控芯片技术 药物活性 细胞阵列芯片 “器官”芯片 模式生物芯片 秀丽隐杆线虫 

分 类 号：R917[医药卫生—药物分析学]