体重变化与空腹血糖变化的5年随访研究  

Follow-up studies on changes of weight changes and fasting plasma glucose

作　　者：郝志华[1] 王俊明[1] 李岩[1] 李玲[2] 翟俊轻[1] 魏静[1] 

机构地区：[1]河北省人民医院体检中心,河北石家庄050057 [2]河北医科大学研究生院

出　　处：《现代预防医学》2013年第23期4401-4403,共3页Modern Preventive Medicine

基　　金：河北省卫生厅2012年医学科学研究重点课题

摘　　要：目的探讨体重变化对2型糖尿病发病的影响。方法选取2006—2011年连续在某院体检中心体检并排除基线患有恶性肿瘤、冠心病、糖尿病史及空腹血糖（fastingplasmaglucose．FPG）≥5．6mmol／L人群，比较5年中不同体重变化下FPG变化率．运用Logistic回归模型分析研究体重变化与FPG变化的关系。结果随着基线体重的增加．随访过程中FPG变化越明显，偏瘦组（13．48％）、正常组（29．67％）、超重组（48．92％）、肥胖组（57．18％）各组间比较FPG变化差异均有统计学意义；在随访过程中体重未控制组FPG变化（49．18％）高于体重保持正常或控制组（29．46％）；与随访过程中体重保持正常相比，保持肥胖组有可能发展成糖尿病的危险性最大RR为2．953，95％CI为2．288～3．811，其次为超重转为肥胖组，RR为2．267，95％CI为1．155～3．305，而肥胖转为超重组RR为1．673，95％CI为1．051～2．661危险性要小于保持超重组RR为1．899，95％CI为1．194～2．262及超重转为肥胖组，正常转为超重组RR为1．537，95％CI为1．155～2．046危险性亦高于体重保持正常组。结论有效的体重控制可以降低糖尿病的发病风险。OBJECTIVE To investigate the influence of weight change on morbidity of type-II diabetes. METHODS Selected patients who had taken physical examination uninterruptedly in the medical center of our hospital from 2006 to 2011 and elim- inated those had been attacked by the diseases of malignant tumor, coronary heart disease, or had diabetes history or their fasting plasma glucose （FPG） ≥5.6mmol/L crowd, and compares the FPG rate under different weight changes in the five years as well as the correlations between these two changes by means of logistic regression model analysis. RESULTS With the increase of baseline weight, FPG changed obviously in the follow-up visit, and the differences of FPG changes between groups, skinny group （13.48%）, normal group （29.67%）, overweight （48.92%）, obesity group （57.18%）, had statisti- cal significance. In the follow-up visit, the FPG changes of those whose weight had not been controlled （29.46%） were high- er than that of groups whose weight were normal or controlled as normal （49.18%） ; compared with normal weight persons, the obesity group may has the greatest risk to develop into diabetes, whose RR was 2.953, 95% of whose CI was 2.288- 3.811, followed by overweight-to-obesity group, whose RR was 2.267, 95% of whose CI was 1.155-3.305, while obesity- to-overweight group, whose RR was 1.673, 95% of whose CI was 1.051-2.661, their risk of diabetes disease was lower than overweight group, whose RR 1.899, 95% CI 1.194 to 2.262, and overweight-to-obesity group, and the normal-to-over- weight group, whose RR was 1.537, 95% of whose CI was 1.155~2.046, their risk of diabetes disease was also higher than normal weight group. CONCLUSION The risk of diabetes disease can be 1educed by effective control of one＇s weight.

关 键 词：体重变化 空腹血糖变化 随访 

分 类 号：R587.1[医药卫生—内分泌]