肺动脉高压的人口学特征及病因构成分析  

Analysis of the demographic characteristics and the composition of the related causes of patients with pulmonary hypertension

作　　者：郭璐[1] 刘跃建[1] 解郑良[1] 杨阳[1] 周仲伟[1] 陈庆[1] 邹俊[1] 

机构地区：[1]四川省医学科学院.四川省人民医院呼吸内科,四川成都610072

出　　处：《现代预防医学》2013年第23期4404-4408,4411,共6页Modern Preventive Medicine

基　　金：四川省卫生厅科研项目(090442)

摘　　要：目的通过单中心分析不同病因肺动脉高压（Pulmonaryhypertension，PH）患者人口学特征和病因构成，有助于了解西部地区PH的患病情况及趋势。方法对2006年1月～2010年12月5年间四川省医学科学院·四川省人民医院门急诊及住院部诊断符合PH的2240例患者进行研究，分析其人口学特征和病因构成。结果2006-2010年共收集到门急诊及住院部诊断符合PH的患者2240例，占门急诊住院总人数0．172％o，其中男性1180例，女性1060例（男：女=1．11：1），平均年龄（58．10-4-22．53）岁。21～50岁年龄组，女性患者人数多于男性；〈20岁和51～60岁年龄组，男性患者人数多于女性（P〈0．05）。2240例患者中，呼吸系统疾病和／或缺氧相关性PH812例（36．25％），动脉性PH624例（27．86％），左心疾病相关性PH560例（25．00％），未明确的多种因素所致PH155例（6．92％），慢性血栓栓塞性PH89例（3．97％）。发病例数最多的前5位PH亚型为：慢性阻塞性肺疾病（453例，20．22％）、左心收缩功能障碍（274例，12．23％）、先天性心脏病（259例，11．56％）、心脏瓣膜病（225例，10．05％），慢性高原病（205例．9．15％）。结论PH可发生于任何年龄阶段，中位数发病年龄为58．10岁，男女患者人数接近（男：女≈1．11：1）。呼吸系统疾病和／或缺氧相关性PH已经成为该地区继发性PH最常见的一大类病因，其中主要病种为慢性阻塞性肺疾病和慢性高原病。OBJECTIVE To analyze the demographic characteristics and the composition of the related causes of patients with pulmonary hypertension in a single center, in order to know the situation and trend of the disease in the western region of our country. METHODS A total of 2 240 patients diagnosed with PH were enrolled into this study from outpatient department, e- mergency center and inpatient department in Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People＇s Hospital from January 2006 to December 2010. Individual information and the related causes of the patients were collected and record- ed on the standard registry forms. RESULTS Overall, 2 240 patients （0.172%o of the total from outpatient department, e- mergency center and inpatient department） diagnosed with PH were enrolled during 2006-2010. The mean age of the patients was 58.10 ＋ 22.53 years with male/female patient ratio of 1.11 ： 1 （1 180 males, 1 060 females） . Regarding the different genders and ages, we found a significantly higher distribution proportion in female individuals aged 21-50 and a lower one in female individuals aged 〈 20 and 51-60 （P 〈 0.05）. Of the 2 240 patients, 812 （36.25%） were suffered from PH due to chronic lung disease and/or hypoxia, 624 patients （27.86%） were registered as pulmonary arterial hypertension, 560 （25.00%） had PH due to left heart disease, and miscellaneous forms and chronic thromhoembolic pulmonary hypertension were diagnosed in 155 （6.92%） and 89 patients （3.97%） separately. The top 5 subtypes of PH which had the largest num- ber of patients were PH caused by chronic obstructive pulmonary diseases （453, 20.22%）, left ventricular systolic dysfunc- tion （274, 12.23%）, congenital heart diseases （259, 11.56%）, valvular disease （225, 10.05%） and chronic exposure to high altitude （205, 9.15%）, respectively. CONCLUSION PH is a disorder affecting people of all ages. The median age of the patients is 58.10 years old. There is no obvious difference in

关 键 词：肺动脉高压 人口学 病因 特征 

分 类 号：R543.2[医药卫生—心血管疾病]