深圳市龙岗区1～3岁幼儿血清25-羟维生素D2＋D3水平调查  

Serum Levels of 25-Hydroxyvitam D2 and D3 in 1-3-year-old children in Longgang District of Shenzhen

作　　者：王强[1] 李慧丽[1] 宁玉峰 王为实[1] 陈珺汝 卫国[1] 陈淑芬[1] 

机构地区：[1]深圳市龙岗区妇幼保健院儿童保健科,广东深圳518172

出　　处：《海南医学》2013年第22期3342-3343,共2页Hainan Medical Journal

摘　　要：目的 了解目前深圳市龙岗区1～3岁婴幼儿维生素D的营养状况.方法 采用高效液相色谱-串联质谱方法对2011年11月至2013年4月在广东省深圳市龙岗区妇幼保健院儿童保健科门诊进行健康检查的293例1～3岁幼儿进行血清25-羟基维生素D2及25-羟基维生素D3水平检测.结果 血清25-羟基维生素D2＋D3＜ 20 ng/ml （50 nmol/L）检出率为14.3％,其中3岁组儿童检出率最高达27.5％（P＜0.01）;血清25-羟基维生素D2＋D3≤30 ng/ml （75 nmol/L）检出率为38.2％;血清25-羟基维生素D2＋D3＞30 ng/ml （75 nmol/L）检出率为47.4％;1岁及2岁组血清25-羟维生素D2＋D3水平均高于3岁组幼儿（P＜0.01）.结论 深圳市龙岗区大于2岁的幼儿及学龄前儿童不应忽视维生索D的补充,2岁前补充维生素AD滴剂依从性不好的幼儿应及时检测25-羟基维生素D水平,适时补充维生索D.Objective To know the nutritional status of 25-hydroxyvitamin D in 1～3-year-old children in Longgang District of Shenzhen.Methods A total of 293 children aged 1～3 years for childcare were selected from Nov.2011 to Apr.2013.Their serum levels of 25-hydroxyvitamin D2 and D3 were detected by performance liquid chromatography tandem mass spectrometry technology.Results The rate of serum levels of 25-hydroxyvitamin D,and D3 under 20 ng/ml （50 nmol/L） was 14.3%,and the rate of serum levels of 25-hydroxyvitamin D2and D3 under 20 ng/ml（50 nmol/L）in 3-year-old children group was 27.5%,which was the highest in all children （P 〈 0.01）.The rate of serum levels of 25-hydroxyvitamin D2 and D3 from 20 ng/ml （50 nmol/L） to 30 ng/ml （75 nmol/L） was 38.2%.The rate of serum levels of 25-hydroxyvitamin D2 and D3 above 30 ng/ml （75 nmol/L） was 47.4%.The serum levels of 25-hydroxyvitamin D2 and D3 in 1-year-old children group and 2-year-old children group were higher than those in 3-year-old children group （P〈 0.01）.Conclusion The Vitamin D supplements shouldn＇t be ignored in children above 2 years and preschool children.If the children hadn＇t supplemented Vitamin AD by their doctors before age 2,they should be detected their serum levels of 25-hydroxyvitamin D and supplement Vitamin D in good time.

关 键 词：25-羟基维生素D2+D3 维生素D缺乏 儿童 

分 类 号：R195[医药卫生—卫生统计学]