腰-硬联合阻滞麻醉对产妇皮质醇、IL-10、IL-18水平的影响  

Effect of Combined Spinal-epidural Analgesia on Serum Cortisol,IL-10,IL-18 Levels in Patients with Pregnant Women

作　　者：肖加旺[1] 

机构地区：[1]江苏省连云港市东方医院,222042

出　　处：《放射免疫学杂志》2013年第6期727-728,共2页Journal of Radioimmanology

摘　　要：目的:探讨了腰-硬联合麻醉对产妇皮质醇、IL-10、IL-18水平的影响。方法:60例足月孕妇随机分为腰-硬联合阻滞(CSEA)、分娩镇痛组(A组)和未行镇痛的对照组(B组),每组30例。A组行CSEA(0.1%罗哌卡因+2μg/ml芬太尼)分娩镇痛,两组产妇均采用放免法测定皮质醇,酶联法测定IL-10、IL-18水平。结果:A组皮质醇、IL-10、IL-18水平明显低于B组(P<0.05)。结论:CSEA能有效地减轻疼痛应激反应,有利于患者的细胞因子的平衡。Objective To explore the effect of combined spinal-epidural analgesia of serum cortisol, IL-10, IL-18 levels in patients with pregnant women. Wethods 60 cases in spontaneous labor were randomly divided into 2 groups with 30 eases each. The patients in group A were given CSEA with fentanyl 20μg in labor analgesia and ropivacaine（0.1% ） combined with fentanyl（2μg/ml） inepidural analgesia. The patients in group B were not given labor analgesia as the control. Serum cortisol（ with RIA）, serum IL-10, IL- 18 （with ELISA） levels were detected in pregnant women. Results The levels of cortisol, IL-10, IL-18 levels significantly lower than those in B groups （P 〈 0.05）. Conclusion CSEA could shorten the active delivery reaction, and may benefit the balance of cytokines in patients.

关 键 词：腰-硬联合阻滞 产妇 分娩镇痛 皮质醇 白细胞介素-10 白细胞介素-18 

分 类 号：R719.8[医药卫生—妇产科学]