乳腺癌患者手术前后血浆leptin和血清PRL、E_2、TSGF检测的临床意义  

Clinical Significance of Determination the Changes on Plasma Leptin Serum PRL,E_2 and TSGF Levels After Operation in Patients with Breast Cancer

作　　者：章惠刚[1] 黄平[1] 付美丽[1] 

机构地区：[1]江苏省东海县人民医院检验科,222300

出　　处：《放射免疫学杂志》2013年第6期797-799,共3页Journal of Radioimmanology

摘　　要：目的:探讨乳腺癌手术治疗前后血浆leptin和血清PRL、E2和TSGF水平的变化及临床意义.方法:应用酶联免疫吸附试验法、电化学发光法、化学法对33例乳腺癌患者进行了手术治疗前后血浆leptin和血清PRL、E2和TSGF检测,并与35名正常健康人作比较。结果:乳腺癌患者手术治疗前血浆leptin和血清PRL、E2和TSGF水平均显著地高于正常人组(P<0.01),经手术治疗3个月后与正常人组比较无显著性差异(P>0.05),且血浆leptin水平和血清PRL、E2和TSGF水平呈显著正相关(r=0.6139、0.5821、0.4982,P<0.01)。结论:leptin和PRL、E2和TSGF的变化参与了乳腺癌的发生与发展。Objective To explore the clinical relevance of changes on plasma Leptin serum PRL, E2 and TSGF levels after oper-ation in patients with Breast Cancer. Methods Plasma Leptin（with ELISA）, serum PRL, E2 （with ECLI）, serum TSGF（with chem- istry） levels in 33 patients with Breast Cancer and compared with 35 normal heathy individualls as controls. Results Before operation plasma Leptin serum PRL, E2 and TSGF levels presented obviously higher than those in controls （ P 〈 0. 01 ）. After operation for 3 months, the plasma Leptin serum PRL, E2 and TSGF levels showed no more difference from those in controls （P 〉 0.05）. Plasma Lep- tin level was positively correlated with serum PRL, E2 and TSGF levels （ r = 0. 6139,0.5821,0.4982, P 〈 0.01 ）. Conclusion The plasma Leptin and serum PRL, E2 and TSGF levels proved positively correlated to the development of Breast Cancer.

关 键 词：乳腺癌 瘦素 垂体泌乳素 雌二醇 肿瘤特异性生长因子 

分 类 号：R589.2[医药卫生—内分泌]