COPD患者治疗前后血清IL-18、D-D和APN检测的临床意义  

Clinical Significance of Determination of Changes on Serum IL-18,D-D and APN Levels After Treatment in Patients with Chronic Obstructive Pulmonary Diseases( COPD)

作　　者：杨义伟[1] 

机构地区：[1]江苏省金坛市人民医院,213200

出　　处：《放射免疫学杂志》2013年第6期812-813,共2页Journal of Radioimmanology

摘　　要：目的:探讨了COPD患者治疗前后血清IL-18、D-D和APN水平的变化及临床意义。方法:应用酶联法和生化法对40例COPD患者进行了治疗前后血清IL-18、D-D和APN检测,并与35名健康人作比较。结果:COPD患者在治疗前后血清IL-18、D-D和APN水平均非常显著地高于正常人组(P<0.01),经治疗2周后则与正常人组比较无显著性差异(P>0.05),且血清IL-18水平与D-D、APN水平呈显著正相关(r=0.5018、0.6134,P<0.01)。结论:检测COPD患者血清IL-18、D-D和APN水平的变化对了解病情、观察疗效和预后判定均具有一定的临床意义。Objective ＇To explore the clinical significance of changes on serum IL-18, D-D and APN levels after treatment in patients with COPD. Methods Serum IL-18, APN（with ELISA）, serum D-D（with biochemistry） levels were determined in 40 patients with COPD and 35 healthy persons served as controls. Results Before treatment, serum IL-18,D-D, and APN levels showed marked- ly higher than those in controls（P 〈0.01）, after treatment for 2 weeks, TL-18, D-D, and APN levels proved no much different from those in controls （ P 〉 0.05 ）. Serum IL-18 levels were positive correlated with serum D-D, APN levels （ r = 0. 5018,0. 6134, P 〈 0.01 ）. Conduction Changes of serum IL-18, D-D and APN levels monitoring the severity and progress of diseases might be of impor- tant clinical values in patients with COPD.

关 键 词：慢性阻塞性肺疾病 白细胞介素-18 D-二聚体脂联素 

分 类 号：R753.9[医药卫生—皮肤病学与性病学]