荔枝草对小鼠小肠运动研究  

Research on Influence of Salvia Plebeian Exerts upon Mice Intestinal Motility

作　　者：于潇华[1] 于琳琳[1] 马腾[1] 王德媛 刘凯[1] 王世建[1] 宋小莉[1] 

机构地区：[1]山东中医药大学,山东济南250014

出　　处：《辽宁中医药大学学报》2013年第12期60-61,共2页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：大学生研究训练计划(SRT)项目(2011-06);山东省自然基金项目(ZR2010HQ028;ZR2011HM056);山东省中医药科技发展计划项目(2009-256)

摘　　要：目的：采用炭末测定法观察中药荔枝草对小鼠小肠运动的影响。方法：将70只实验小鼠随机分为阳性对照组（枳壳水煎剂组）、荔枝草水煎剂组（10、15、20、25、30g/kg）和生理盐水组,灌胃3d（均为0.2mL/10g）后采用炭末测定法对小鼠的小肠运动情况进行观察分析。结果：荔枝草水煎剂组对小鼠小肠推进率比生理盐水组的推进率明显提高（P〈0.05）;荔枝草水煎剂浓度在10~20g/kg范围内对小肠的推进率逐渐增强,在20~30g/kg范围内其效果逐渐减弱。结论：荔枝草水煎剂有一定的促小肠运动作用,并呈现一定的量效关系,其中以20g/kg浓度的荔枝草水煎剂对小鼠小肠的推动作用最为显著。Objective： To study the influence of salvia plebeian exerts upon mice intestinal motility through carbon powder measurement method. Method： 70 mice were randomly divided into positive control group （fructus aurantii decoction groups ）/salvia plebeian decoction group （ 10 g/kg, 15 g/kg,20 g/kg,25 g/kg, 30 g/kg ）and saline group （ respectively 0.2 mL/ 10 g ）, and after 3 days carbon powder measurement method was adopted to observe and analyze mice intestinal motility. Results ： With regards to the impact upon intestinal motility, insalvia plebeian decoction group was more obvious than saline group （P〈0.05）; within the concentration range of 10-20 g/kg, insalvia plebeian decoction gradually increased intestinal motility, while within 20-30 g/kg the effect weakened slowly. Conclusion ： Insalvia plebeian decoction exerts impact on intestinal motility, which shows a certain dose-effect relationship, among which insalvia plebeian decoction with concentration rate of 20 g/kg has the most significant influence upon mice intestinal motility.

关 键 词：荔枝草 小肠推进率 浓度梯度 

分 类 号：R282.71[医药卫生—中药学]