晚期糖化终末产物受体基因多态性与糖尿病动脉硬化关系的研究进展  

Research Progress in Relationship between Gene Polymorphisms of AGEs Receptor and Diabetic Atherosclerosis

作　　者：叶静思[1] 李希圣[1] 林夏鸿[1] 

机构地区：[1]福建医科大学第二临床医学院内分泌科,福建泉州362000

出　　处：《医学综述》2013年第22期4033-4035,共3页Medical Recapitulate

基　　金：泉州市科技项目(2010Z26);福建医科大学教授基金(68)

摘　　要：糖尿病微血管和大血管并发症是糖尿病患者致死、致残的主要原因,动脉硬化是糖尿病血管病变的主要病理改变。晚期糖化终末产物(AGEs)和晚期糖化终末产物受体(RAGE)相互作用,激活细胞内一系列信号转导途径,是产生和加剧糖尿病动脉硬化的重要机制。RAGE基因定位于染色体6p21.3,包含11个外显子和10个内含子。迄今为止,已经有30多个RAGE基因多态性位点被证实,其中多个RAGE基因多态性位点,特别是-374T/A、-429T/C、G82S与糖尿病动脉硬化相关。但RAGE基因多态性影响糖尿病动脉的机制尚不清楚。The mortality and morbidity of diabetes patients are due to the microvascular and macrovascular complications. Atherosclerosis is the cause of vascular complications in diabetes. The interaction of advanced glycation end-products（AGEs）and the receptor for AGEs（RAGE）, inducing activation some intracellular signal pathways, plays a pivotal role in atherosclerosis. RAGE gene locates in chromosome 6p21.3, including 11 exons and 10 introns. So far at least thirty RAGE gene polymorphisms have been identified, many of which such as -374T/A, -429T/C and G82S are related to diabetic atherosclerosis. Until now the mechanisms of how RAGE gene polymorphisms affect diabetes atherosclerosis are still unclear.

关 键 词：糖尿病 晚期糖化终末产物受体 基因多态性 动脉硬化 

分 类 号：R587.2[医药卫生—内分泌]