妊娠免疫耐受机制的研究进展  

Research Progress of the Mechanism in Immune Tolerance during Pregnancy

作　　者：孙风艳[1] 王萍萍[1] 田花香[1] 王增艳 胡吉英[1] 王增芳[1] 

机构地区：[1]潍坊市妇幼保健院妇产科,山东潍坊261000 [2]诸城市人民医院麻醉科,山东诸城262210

出　　处：《医学综述》2013年第22期4054-4057,共4页Medical Recapitulate

摘　　要：妊娠是一个复杂而又协调的生理过程,母-胎界面正常免疫耐受的建立和维持是妊娠成功与否的关键。母体胎盘、激素水平、黏附分子、细胞因子、人类白细胞抗原、自然杀伤细胞、调节性T淋巴细胞等在母-胎免疫耐受过程中均有重要作用。此外,吲哚胺2,3-双加氧酶作为一种分解代谢酶,其自身的表达调控及其与多种免疫因子、免疫细胞的相互作用在妊娠免疫耐受中也发挥着重要而复杂的作用。Pregnancy is a complex and harmonious physiological process. The establishment and mainte- nance of maternal-fetal immunological tolerance is critical for normal pregnancy. The maternal placenta,level of hormones, adhesion molecule, cytokines human leukocyte antigen natural killer cell and regulatory T cell play important roles in maternal-fetal immunological tolerance. Additionally, the indoleamine 2,3-dioxygen- ase a catabolic enzyme, exerts vital and complex effects on maternal-fetal tolerance by regulating its self- expression and interactions with a variety of immune molecules and ceils.

关 键 词：吲哚胺2 3-双加氧酶 色氨酸 妊娠 T细胞 免疫耐受 

分 类 号：R714[医药卫生—妇产科学]