葛根素对急性肺损伤大鼠肺组织MPO活性及ICAM-1表达的影响  

Effect of Puerarin on Activity of MPO and Expression of ICAM-1 in Rats with Acute Lung Injury

作　　者：吴春艳[1] 张智[2] 谷玮玮[3] 鲍世英 李爱斌[1] 

机构地区：[1]保定市第一中心医院,河北保定071000 [2]河北大学基础医学院 [3]河北医科大学第三医院 [4]顺平县医院

出　　处：《中国药师》2013年第11期1653-1655,共3页China Pharmacist

摘　　要：目的:观察葛根素对急性肺损伤(ALI)时肺组织的保护作用及其可能机制。方法:24只大鼠随机分为3组:对照组、油酸组和葛根素预处理组,检测肺组织髓过氧化物酶(MPO)的活性变化和细胞间黏附分子-1(ICAM-1)的表达变化。结果:与对照组相比,油酸组肺组织MPO活性及ICAM-1的表达均显著增加(P<0.05);与油酸组相比,葛根素预处理组肺组织MPO活性及细胞间ICAM-1的表达均明显降低(P<0.05),但仍高于对照组(P<0.05)。结论:葛根素可通过提高MPO及ICAM-1的表达,有效减轻ALI时肺组织的炎症反应。Objective： To investigate the protective effect of puerarin （Pue） on the acute lung injury （ALl） in rats and the possi- ble mechanism. Method ： Twenty-four rats were randomly divided into three groups, control group, oleie acid （ OA ） group and Pue group. The activity of myeloperoxidase （MPO） and the expression of intercellular adhesion molecule-1 （ICAM-1） in lung tissues were examined. Result： Compared with the control group, the activity of MPO and the expression of ICAM-1 in lung tissues were increased obviously in OA group （P 〈 0.05）. Compared with those in OA group, the activity of MPO and the expression of ICAM-1 in lung tis- sues were decreased obviously in Pue group （ P 〈 0.05 ） , while were still higher than those in the control group （ P 〈 0.05 ）. Conclu- sion ： Puerarin can attenuate inflammation reaction in lung tissues during ALI through increasing the activity of MPO and inhibiting the expression of ICAM-1.

关 键 词：葛根素 急性肺损伤 油酸 细胞间黏附分子-1 髓过氧化物酶 

分 类 号：R285.5[医药卫生—中药学]