COMT基因第四外显子与帕金森遗传易感性关系的研究  

Research on relationship between COMT gene exon four and Parkinson's genetic susceptibility

作　　者：齐丹[1] 戴艳萍[1] 陈晓光[1] 李军[1] 张春媛[1] 

机构地区：[1]黑龙江省医院,黑龙江哈尔滨150001

出　　处：《中医临床研究》2013年第21期87-88,共2页Clinical Journal Of Chinese Medicine

基　　金：黑龙江省卫生厅课题;课题编号2012-398

摘　　要：目的:探讨研究人群儿茶酚胺氧位甲基转移酶(Catechol-O-Methyl Transferase,COMT)基因第四外显子G/A多态性与帕金森病(Parkinson Disease,PD)遗传易感性的相关性研究。方法:采用聚合酶链反应-限制性片段长度多态方法,观察90例PD患者及95例健康对照个体COMT基因多态分布,通过其比值研究COMT基因变异与PD发作相关性。结果:①PD患者与正常人群之间存在COMT基因第四外显子G/A各等位基因频率分布的差异(P<0.05);相关分析提示PD与COMT基因第四外显子存在关联(P<0.05)。②按年龄分组后分析显示≤60岁组人群及>60岁组人群中均存在COMTG/A多态在PD患者与正常组的差异(P<0.05)。结论:研究结果未发现COMT基因G/A多态性与帕金森病遗传易感性具有相关性。Objective： To investigate the correlation researches of catechol-o-methyltransferase （COMT） gene exon four G/A polymorphism and Parkinson disease （PD） genetic susceptibility. Methods： Adoption polymerase chain reaction-restriction fragment length polymorphism method was observed in 90 patients with PD and 95 healthy control individual COMT gene polymorphism distributions, through the study of ratio of COMT gene mutation and PD attack correlation. Results： （1） Patients with PD between PD patients and normal people COMT gene exon four G/A allele frequency distribution have differences （P〈0.05）, correlation analysis showed that PD and COMT gene exon four have association （P〈0.05）. （2）According to the age group analysis showed that there were differences of COMTG/A polymorphism in PD patients between≤ 60 years of age group and〉60 years of age group population （P〈0.05）. Conclusion： The results did not find correlation between COMT gene G/A polymorphism and PD genetic susceptibility.

关 键 词：帕金森病 儿茶酚胺氧位甲基转移酶 基因 第四外显子 

分 类 号：R322.8[医药卫生—人体解剖和组织胚胎学]