3,5-二溴-2-氨基吡嗪的合成  

The Synthesis of 3,5-Dibromopyrazin-2-Amine

作　　者：郑国祥 邓斌 

机构地区：[1]杭州澳赛诺化工有限公司,浙江杭州310030

出　　处：《浙江化工》2013年第11期24-24,42,共2页Zhejiang Chemical Industry

摘　　要：以廉价易得的2-氰基吡嗪作为起始原料,经水解、重排、水解一锅法得到2-氨基吡嗪,再用NBS溴化得到3,5-二溴-2-氨基吡嗪。本方法反应时间短,条件温和,具有较高的应用价值。2-Amino pyrazine was prepared via hydrolysis, rearrangement and hydrolysis of one pot by using 2-cyanopyrazine, which is an inexpensive and easily available raw material. Then 3,5-dibromopyrazin- 2-amine was got via NBS bromination. This method had short reaction time, mild conditions and higher application value.

关 键 词：2-氰基吡嗪 次氯酸钠 NBS 3 5-二溴-2-氨基吡嗪 

分 类 号：TQ463.5[化学工程—制药化工]