川崎病外周血中性粒细胞CD64表达的临床意义  

Clinical significance of peripheral blood neutrophil CD64 in Kawasaki disease

作　　者：郑丽云[1] 江荣[1] 赵胜[1] 刘海鹏[1] 杨贵明[1] 程邦宁[1] 

机构地区：[1]安徽医科大学儿科临床学院安徽省立儿童医院心内科,合肥230051

出　　处：《中华实用儿科临床杂志》2013年第21期1637-1639,共3页Chinese Journal of Applied Clinical Pediatrics

摘　　要：目的观察外周血中性粒细胞CD64在川崎病（KD）中的表达水平及临床意义。方法选择2011年7月至2012年10月在安徽省立儿童医院心内科住院患儿中收集的54例KD患儿，根据心脏彩超分为无冠状动脉损伤组（41例）和冠状动脉损伤组（13例），30例脓毒症患儿为脓毒症组，10例健康体检儿童为健康对照组，采用流式细胞仪检测各组外周血CD64指数。结果治疗前KD组CD64指数（7．02±3．21）与脓毒症组（11．25±5．14）均显著高于健康对照组（2．45±0．52），但KD组显著低于脓毒症组（P〈0．01）；冠脉损伤组CD甜指数（5．74±3．09）与无冠状动脉损伤组（7．43±3．17）比较差异无统计学意义；治疗后无冠状动脉损伤组CD64指数（2．63±0．69）与冠状动脉损伤组（2．56±0．73）均较治疗前明显降低，差异有统计学意义（P均〈0．01）。结论中性粒细胞CD64在KD患儿中表达升高，其升高程度可能对KD和脓毒症的鉴别有一定临床意义，或可作为预测疾病转归的灵敏指标。Objective To investigate the expression level of peripheral blood neutrophil CD64 in Kawasaki di- sease （KD）, and explore its clinical significance. Methods Fifty-four patients with KD were divided into 2 groups [ 13 patients with coronary artery lesions（CAL） and 41 patients without CALl ,and 30 age-matched patients with sepsis and 10 healthy children were studied. The levels of peripheral blood neutrophil CD64 was measured by flow cytometry. Results Before treatment, the levels of CD64 in children with KD （7.02± 3.21 ） and sepsis （ 11.25 ± 5.14 ） were sig- nificantly higher than the healthy children （ 2.45±0.52 ） , and the level of CD64 in the KD group was significantly lower than that in sepsis group（ P 〈 O. 01 ）. CD64 index were significantly elevated in the 2 groups of KD patients before treat- ment （CAL group ：5.74 ± 3.09 ;without CAL ：7.43 ±3.17 ）. There was no significant difference in the CD64 level be- tween KD patients with CAL and without CAL. CD64 index in the 2 groups of KD patients after treatment （ CAL group ： 2.56 ± 0.73 ;without CAL：2.63 ± 0.69 ） were significantly lower than those before treatment （ all P 〈 0.01 ）. Conclusions The expression of peripheral blood neutrophil CD64 in KD is significantly elevated. The degree of elevation in CD64 possibly has clinical meaning in differentiating KD from sepsis, and it can be a sensitive factor of disease outcome.

关 键 词：川崎病 脓毒症 CD64 

分 类 号：R725.4[医药卫生—儿科]