北极刺参岩藻聚糖硫酸酯对糖尿病小鼠胰岛素抵抗的改善作用  

Study on the alleviating effects of Thelenata anaxsulfated fucan on the insulin resistance of diabetic mice

作　　者：石迪[1] 王静凤[1] 胡世伟[1] 张珣[1] 常耀光[1] 王玉明[1] 薛长湖[1] 

机构地区：[1]中国海洋大学食品科学与工程学院,山东青岛266003

出　　处：《中国海洋药物》2013年第6期72-78,共7页Chinese Journal of Marine Drugs

基　　金：海洋公益性行业科研专项(201105029);"十二五"国家科技支撑计划(2012BAD33B07);长江学者和创新团队发展计划资助

摘　　要：目的研究北极刺参岩藻聚糖硫酸酯(Thelenata anaxsulfated fucan,Ta-FUC)对2型糖尿病小鼠胰岛素抵抗症状的改善作用。方法以高脂高糖饮食建立2型糖尿病小鼠模型,以含有0.04%和0.16%TaFUC的饲料分别连续饲喂小鼠11周,实验结束后,称量白色脂肪组织重量,检测各组小鼠空腹血糖、葡萄糖耐受量,及空腹血清胰岛素、脂联素、瘦素、肿瘤细胞坏死因子-α(TNF-α)含量。结果Ta-FUC可降低模型小鼠体重(P<0.05),减少小鼠白色脂肪组织重量(P<0.01);并显著降低模型小鼠空腹血糖(P<0.05),提高口服葡萄糖耐受量(P<0.01),降低空腹血清胰岛素水平(P<0.05);同时还可降低血清中瘦素和TNF-α的含量(P<0.05,P<0.01)。结论北极刺参岩藻聚糖硫酸酯对模型小鼠的胰岛素抵抗具有显著的改善作用,其作用机理可能与改善肥胖引起的脂肪组织细胞因子的分泌紊乱有关。Objective To study the alleviating effects of Thelenata anaar sulfated fucan （Ta-FUC） on the insulin resistance of type Ⅱ diabetic mice. Methods The type 2 diabetic mice model was induced by high-fat and high-sugar diet. The mice were treated with the diet containing 0.04% and 0. 16% Ta-FUC for 11 weeks respectively and the mice＇s white adipose tissues were weighed afterwards. The fast-ing plasma glucose and oral glucose tolerance were tested and the fasting plasma insulin concentration, the levels of plasma adiponeetin, leptin together with TNF-α were detected. Results The Ta-FUC could lower the body and white adipose tissues weight of the mice （P〈0.05, P〈0.01）. Meanwhile, it could lower the level of fasting plasma glucose and insulin level （P〈0.05）, improve the glucose tolerance （P〈0.01）. Besides, it could also decrease the secretion of leptin （P〈0. 05） as well as the content of TNF-α in plasma （P〈0.01）. Conclusion The Ta-FUC has a significant alleviating effect on the insulin resistance of the model mice, whose mechanism may be pose cytokines induced by obesity. related to relieving the parasecretion of the adi

关 键 词：北极刺参岩藻聚糖硫酸酯 糖尿病 胰岛素抵抗 瘦素 肿瘤坏死因子-Α 

分 类 号：Q493.5[生物学—生理学]