以蛤蜊壳为钙源的L-焦谷氨酸钙制备工艺  

Preparation technology of calcium bis-L-pyroglutamate from clam shell

作　　者：魏玉西[1] 崔育倩[2] 王文秀[1] 宋惠平[1] 柳翠青 艾桂花[1] 

机构地区：[1]青岛大学医学院生物系,山东青岛266071 [2]青岛大学化学与环境学院,山东青岛266071

出　　处：《中国海洋药物》2013年第6期83-86,共4页Chinese Journal of Marine Drugs

基　　金：青岛市科技计划项目(13-1-3-73-nsh)资助

摘　　要：目的为了高值化利用海洋生物资源,以蛤蜊加工产生的大量废弃物——蛤蜊壳为钙源制备L-焦谷氨酸钙。方法蛤蜊壳经去除附着物、粉碎、水飞法处理等预处理步骤制成粉末状钙源蛤蜊壳粉,使之与L-焦谷氨酸直接进行合成反应合成L-焦谷氨酸钙。为了获得最佳工艺条件,在蛤蜊壳粉过量的前提下,采用正交设计法考察了反应温度、反应时间对L-焦谷氨酸钙产量的影响,筛选了L-焦谷氨酸钙分离方法。结果在反应温度为60℃,反应时间为3h,采用真空浓缩到一定程度后再用95%乙醇使其结晶和重结晶,焦谷氨酸钙的产率最大可达88.82%。结论该工艺具有工艺简便、耗能少、产率高等特点,既可以将蛤蜊壳高值化利用制得性能优良的补钙健脑食品,又能解决蛤蜊壳对环境的污染问题。Objective To make full use of marine biological resources, clam shell was utilized as calcium source to synthesize calcium L pyroglutamate. Methods Clam shell powder which was obtained by pre treatment including removing surface attachments, grinding and powder-refining with water, reacted directly with L-pyroglutamic acid. In order to obtain the best technology condition, the means of or thogonal design was applied for screening reaction temperature and time under the condition of excess clam shell powder, and the separation method of calcium bis- L-pyroglutamate from the reaction mix-ture was also studied. Results The results showed that calcium his-L-pyroglutamate yield was up to 88. 82% when the reaction was carried out at 60℃ for 3 h, and tim end mixture was condensed by wicuum concentration, and then 95 % alcohol was used for the crystallization and recrystallizalion of calcium his L-pyroglutamate. Conclusion This technology has many beneficial characteristics such as simple process, low energy cost and high yield, h is a new way not only to make full use of the low price a-quatic products to produce foods with brain strengthening and calcium supplying functions, but also to solve the pollution caused by clam shell to the environment.

关 键 词：蛤蜊壳 L-焦谷氨酸钙 工艺条件 红外光谱 

分 类 号：TQ460.6[化学工程—制药化工]