再生细菌纤维素膜的制备与性能表征  

Preparation and characterization of regenerated bacterial cellulose membrane

作　　者：朱勇军[1,2] 任力[1,2] 李立风[1,2] 刘卅[1,2] 季培红 

机构地区：[1]华南理工大学材料科学与工程学院,广东广州510641 [2]国家人体组织功能重建工程技术中心,广东广州510641 [3]广州华美康联生物科技有限公司,广东广州510000

出　　处：《功能材料》2013年第23期3474-3477,3480,共5页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(51273072;50803018);"十二五"国家科技支撑计划资助项目(2012BAI17B02);广东省重大科技专项资助项目(2012A080203010);广东省教育部产学研结合资助项目(2010B090400416)

摘　　要：采用LiCl/DMAc的溶解体系将细菌纤维素溶解后制备再生细菌纤维素(RBC)膜,并研究了成膜的细菌纤维素溶液浓度对膜的结晶度、平衡含水率、透光率以及对营养物质(氯化钠、葡萄糖、色氨酸)的透过性能的影响。实验结果表明,随着成膜溶液浓度的升高,再生膜的结晶度有一定程度的降低;平衡含水率稍有升高;再生膜干态下的透光率变化不大,但浸泡PBS后膜变化较大;对营养物质的透过系数随浓度变化较小,对葡萄糖和色氨酸的透过系数相近,约为1.0×10-6cm2/s,氯化钠的透过率系数约为2.5×10-6cm2/s。研究表明再生细菌纤维素膜是一种潜在的人工角膜板层移植材料。In this work, regenerated bacterial cellulose （RBC） membrane was prepared by LiCl/DMAc, and influence of the concentration of bacterial cellulose solution on crystallinity, equilibrium water content, light transmittance and the diffusion of nutrients （sodium chloride, glucose sugar, tryptophan） of RBC membrane were studied. The experimental results showed that, with the concentration of bacterial cellulose solution increasing, the degree of crystallinity of regenerated membrane slightly decreased; equilibrium water content increased slightly and light transmittance of dry films changed little, but that of wet films changed obviously; the diffusion coefficient to nutrients hardly changed with the BC solution concentration, and that to glucose sugar and tryptophan were approximately 1.0 ×10^-6cm^2/s, and the sodium chloride permeability coefficient was about 2.5 ×10^-6cm^2/s. This work indicated that RBC membrane was promising biomaterial for corneal lamellar transplantation application.

关 键 词：细菌纤维素 氯化锂 N N二甲基乙酰胺 再生细菌纤维膜 渗透性 

分 类 号：O636.1[理学—高分子化学]