膦甲酸钠抗乙肝病毒的近期疗效  

Clinical study of the short-term efficacy of foscarnet sodium in treatment of hepatitis B

作　　者：张珍武[1] 蔡淑清 叶进 罗端德 李淑莉 曾令兰 吴国栋[2] 徐志斌[3] 覃宗坦 

机构地区：[1]华中科技大学同济医学院协和医院传染科,武汉430022 [2]荆州市第二人民医院感染科,荆州434000 [3]武汉市第一医院传染科,武汉430020 [4]宜昌市第三医院,宜昌443000

出　　处：《中国新药杂志》2000年第11期788-790,共3页Chinese Journal of New Drugs

摘　　要：目的 :用Amplisensor定量PCR技术考核短期静脉注射膦甲酸钠治疗慢性乙型肝炎的疗效 ,为膦甲酸钠治疗乙型肝炎的临床推广应用提供科学依据。方法 :选择 2 2例慢性乙型肝炎患者 ,给予膦甲酸钠 2 .4g ,加入5 %葡萄糖液 10 0ml稀释后静脉滴注 ,bid ,用 2 8d ,同时用常规护肝药物 ;对照组 10例仅给予常规护肝药物共 2 8d。检测治疗前后患者血清HBV DNA水平、乙肝三系和肝功能的变化情况。结果 :试验组 2 2例患者中有 14例血清HBV DNA水平在治疗结束时有不同程度的下降 ,平均值 (对数值 )由 7.6 0± 1.41下降为 6 .89± 1.2 8(P <0 .0 5 ) ;12例HBeAg阳性患者中有 3例阴转。对照组 10例患者中有 7例HBV DNA水平下降 ,平均值 (对数值 )由 8.5 0±0 .81下降为 8.2 8± 0 .91(P >0 .0 5 ) ;7例HBeAg阳性患者中无 1例阴转。试验组和对照组之间ALT和T Bil的变化无明显差异。在治疗过程中未发现明显的不良反应。结论 :短期静脉注射膦甲酸钠用于治疗慢性乙型肝炎 ,对抑制乙肝病毒复制具有一定的作用 ,其远期疗效尚待进一步研究。Objective:To investigate the efficacy of foscarnet sodium in treatment of hepatitis B by Amplisensor's quantitative PCR technique.Methods:32 patients with chronic hepatitis B were allocated to receive twice daily foscarnet sodium 2.4g(dissolved in 100 ml of 5% glucose solution)given by difusion plus liver-protective drugs for 28d( n =22) or only liver-protective drugs without any antiviral therapy ( n =10) for 28d.The level of serum HBV-DNA,HBV markers and liver function were measured before and after treatment.Results:In the active group,the serum HBV-DNA level decreased in 14 patients in varing degree with a mean decreasing log-value from 7.60±1.41 to 6.89±1.28 ( P <0.05) and HBeAg truned to negative in 3 patients.In the control group,the serum HBV-DNA level decreased in 7 patients with a mean decreasing log-value from 8.50±0.81 to 8.28±0.91 ( P >0.05) and no patient's HBeAg turned to negative.Conclusion:In treatment of chronic hepatitis B,short-term infusion of foscarnet sodium can inhibits HBV replication but its long-term efficacy need to be investigated. [

关 键 词：膦甲酸钠 定量PCR 乙型肝炎病毒 药理 

分 类 号：R978.7[医药卫生—药品] R512.620.5[医药卫生—药学]