乳剂对人参有效成分透皮吸收的影响  

Effects of Emulsion on in vitro Transdermal Absorption of Active Ingredients from `inseng Radix et Rhizoma

作　　者：马东[1] 刘梦[2] 李超英[2] 高雅言[2] 于慧超[2] 何蕊[2] 

机构地区：[1]长春市人民医院,长春130051 [2]长春中医药大学,长春130117

出　　处：《中国实验方剂学杂志》2013年第23期50-53,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：吉林省科学技术厅项目(Y Y Z X201118)

摘　　要：目的:考察人参提取液和人参乳膏中有效成分的体外透皮吸收能力。方法:采用智能透皮吸收仪,以人参总皂苷和总多糖为考察指标,采用UV测定指标成分含量,通过体外释药试验考察人参提取液制备成乳膏前后指标成分的透皮吸收能力变化。结果:人参乳膏中总皂苷透皮吸收过程符合一级方程,而人参乳膏中总多糖、人参提取液中总皂苷和总多糖的透皮吸收过程均符合Higuchi方程,2种成分的累积释药率分别为82.30%,67.53%。结论:人参乳膏具有良好的透皮能力,可增加有效成分的透皮吸收,为其他透皮给药剂型的研制提供科学依据。Objective： To investigate in vitro transdermal absorption ability of active ingredients from ginseng extract and ginseng creams. Method： Taking intelligent transdermal absorption instrument,with total saponins and total polysaccharides from ginseng Radix et Rhizoma as indexes,which were determined by UV;Before and after ginseng extract were prepared into ginseng creams,percutaneous absorption capacity changes of index components were investigated by in vitro release test. Result： Transdermal absorption process of total saponins from ginseng creams was in line with the first-order equation,but total polysaccharides from ginseng creams and total saponins and total polysaccharides from ginseng extract were in line with Higuchi release equation;After been prepared into ginseng creams,cumulative release rates of these two ingredients were 82.30% and 67.53%,respectively. Conclusion： ginseng creams had good transdermal ability,it could increase transdermal absorption of effective components and provide a scientific basis for research of other transdermal formulations.

关 键 词：人参 乳膏 提取液 促透作用 体外释药规律 

分 类 号：R283.6[医药卫生—中药学]