醒脑益智胶囊对东莨菪碱致小鼠记忆获得障碍模型的影响  

Effects of Xingnao Yizhi Capsule on Learning and Memorizing Consolidation of Dysmnesia Mice Induced by Scopolamine Hydrobromide

作　　者：张晓平[1] 侯林[1] 聂克[1] 崔清华[1] 田景振[1] 

机构地区：[1]山东中医药大学,济南250355

出　　处：《中国实验方剂学杂志》2013年第23期228-230,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：重大新药创制专项-治疗老年性痴呆创新中药(2011ZX09102-003-06)

摘　　要：目的:研究醒脑益智胶囊对东莨菪碱致小鼠记忆获得障碍模型的影响。方法:昆明种小鼠60只随机分为空白对照组,模型组,阳性对照组(石杉碱甲0.05 mg·kg-1),醒脑益智胶囊高、中、低剂量组(179.2,89.6,44.8 mg·kg-1),每组10只。每天ig给药2次,连续15 d进行预防性给药。给药后一次性腹腔注射东莨菪碱(5 mg·kg-1)复制小鼠学习记忆获得障碍模型,避暗法、跳台法测定学习记忆能力,测定脑组织中超氧化物岐化酶(SOD)活力、丙二醛(MDA)的含量。结果:与模型组比较,高剂量组(179.2 mg·kg-1)能在一定程度上延长小鼠潜伏期,减少5 min内错误次数,提高SOD活力,降低MDA的含量,差异具有显著性(P<0.05)。结论:醒脑益智胶囊有促进记忆和改善东莨菪碱致小鼠记忆获得障碍的作用。Objective： To study the effect of Xingnao Yizhi capsule on learning and memorizing consolidation of dysmnesia mice induced by scopolamine hydrobromide. Method： Sixty mice were divide into normal control group,model group, Huperzine-A group（0.05 mg kg-1 ）,Xingnao Yizhi capsule of high dose group, middle dose group and low dose group（179.2,89.6,44.8 mg kg-1）.After the intragastric administration twice a day respectively for 15 days, the learning and memory consolidation of dysmnesia model was induced by scopolamine hydrobromide intraperitoneal injection（5 mg kg-1）. Learning and memory function of various group rats were assessed with step-through test and step-down test;The content of malondiadehyde（MDA）, activity of superoxide dismutase（SOD） in brain tissue were detected. Result： Compared with model group, Xingnao Yizhi capsule（179.2 mg kg-1）prolonged the latency periods of memory and significantly reduced the error times within 5 mins in dysmnesia groups （P〈0.05）, increased the activity of SOD and decreased the content of MDA in brain tissue （P〈0.05）. Conclusion： Xingnao Yizhi capsule has protective effects on learning and memorizing consolidation of dysmnesia mice induced by scopolamine hydrobromide.

关 键 词：醒脑益智胶囊 学习记忆 超氧化物岐化酶 丙二醛 

分 类 号：R285.5[医药卫生—中药学]