循环纤维细胞与器官纤维化  

Circulating fibrocytes and organic fibrosis

作　　者：富徐燕[1] 李彧[1] 李亚东[1] 牛建昭[1] 

机构地区：[1]北京中医药大学基础医学院,北京100029

出　　处：《解剖学报》2013年第6期869-872,共4页Acta Anatomica Sinica

基　　金：国家自然科学基金资助项目(81173642);教育部国家外专局创新引智基地资助项目(B07007)

摘　　要：器官纤维化的发生与细胞外基质(ECM)的过度沉积有关。过去认为组织固有(肌)成纤维细胞是细胞外基质生成的主要细胞,近年来的研究则发现,血液中骨髓来源的循环纤维细胞在纤维化疾病的产生和发展过程起到了重要的作用。活化的循环纤维细胞不仅自身可分泌细胞外基质参与纤维化进程,也能通过分化成为(肌)成纤维细胞来发挥生理性和病理性的纤维化作用。循环纤维细胞具有多种生物学功能,能直接分泌各种细胞因子或促进相关因子的生成来促进纤维化进程。同时,循环纤维细胞的生成、转移、分化及其致纤维化作用也受到了不同的细胞因子和信号通路的调控。我们主要对于近年来循环纤维细胞与器官纤维化的研究进展予以综述。Fibrosis of organs is related with over-accumulation of extracellular matrix （ECM）. It is widely acknowledged that （myo）fibroblasts lead to the formation of extracellular matrix. Recent studies confirm that marrow- derived circulating fiobrocytes play important roles in the formation and process of fibrosis. Activated circulating fibrocytes not only secrete extraeellular matrix that is essential for the process of fibrosis, but also differentiated into （myo）fibroblasts leading to fibrosis, either physiologically or pathologically. Circulating fibrocytes have special characteristics and various bio-funetions, and secrete various eytokines to accelerate the fibrosis. The formation, migration, differentiation and fibrosis-promoting function are also regulated by various cytokines and pathways. This article aims to review the latest development in circulating fibroeytes and organic fibrosis.

关 键 词：循环纤维细胞 器官纤维化 信号通路 

分 类 号：Q291[生物学—细胞生物学]