琥珀酸索利那新联合萘哌地尔治疗女性膀胱过度活动症的临床观察  

A combination of solifenacin succinate and naftopidil in the treatment of female overactive bladder

作　　者：霍立志[1] 井汉国[1] 王腾春[1] 袁守娴[1] 栾秀华[1] 郭克存[1] 史本康[2] 

机构地区：[1]泰山医学院附属聊城市第二人民医院泌尿外科,山东省临清市252600 [2]山东大学齐鲁医院泌尿外科

出　　处：《中华医学杂志》2013年第44期3526-3528,共3页National Medical Journal of China

摘　　要：目的 探讨行为训练效果不佳的女性膀胱过度活动症（OAB）患者的有效治疗方法.方法 选择2012年1月至2013年1月聊城市第二人民医院行为训练效果不佳的女性OAB患者67例,年龄19 ～57岁,平均39.8岁;病程1～16年,平均3.8年.按随机数字表法将67例患者随机分为试验组（n=24）和对照Ⅰ组（n=22）、Ⅱ组（n=21）,试验组给予口服琥珀酸索利那新（5 mg口服,1次/d）及萘哌地尔（25 mg口服,每晚1次）;对照Ⅰ组单纯给予琥珀酸索利那新;对照Ⅱ组单纯给予萘哌地尔.用药时间均为4周.观察试验组与对照组用药前后尿急评分、日平均排尿次数、日平均单次尿量、日单次最大尿量变化,并进行统计学分析.结果 试验组与对照Ⅰ组、Ⅱ组治疗后尿急评分、日平均排尿次数、日平均单次尿量、日单次最大尿量差异均有统计学意义[（0.8±0.1）比（1.8±0.8）、（2.1±0.9）分,（9±4）比（13±4）、（14±5）次,（295 ±79）比（211 ±67）、（185±64） ml,（352±88）比（292 ±75）、（235±69） ml,均P＜0.05].结论 琥珀酸索利那新联合萘哌地尔能够有效改善女性OAB患者的临床症状,提高生活质量.Objective To explore the effective therapy of female overactive bladder unresponsive to behavior training.Methods A total of 67 patients with female overactive bladder unresponsive to behavior training were enrolled from January 2012 to January 2013 at Liaocheng Second People＇s Hospital.They were randomized into trial and control groups（Ⅰ and Ⅱ）.Their mean age was 39.8 （19-57） years.And the mean disease course was 3.8 （1-16） years.The trial group （n =24） received oral formulations of solifenacin succinate （5 mg,once a day）and naftopidil（25 mg,every evening）.The control group Ⅰ （n =22） had only solifenacin succinate and the control group Ⅱ （n =21） only naftopidil.The treatment lasted for 4 weeks.The time of urination per day,average amount of mona-urination and maximum amount of monaurination were observed.The changes of all parameters before and after treatment were assessed.And statistic analysis was performed.Results The urinary urgency score of the trial,control group Ⅰ and control Ⅱ groups were 0.8 ±0.1,1.8 ±0.8,2.1 ±0.9; and the times of urination per day 9 ±4,13 ±4,14 ±5,average amount of mona-urination （295 ± 79）,（211 ± 67）,（185 ± 64） ml and maximum amount of monaurination （352 ± 88）,（292 ± 75）,（235 ± 69） ml respectively.These parameters showed significant differences between the trial and control groups （all P ＜ 0.05）.Conclusion A combination of solifenacin succinate and naftopidil can effectively relieve the symptoms of female overactive bladder and improve the life quality.

关 键 词：膀胱 过度活动性 药物疗法 琥珀酸索利那新 萘哌地尔 

分 类 号：R694[医药卫生—泌尿科学]