白细胞介素10基因-592C／A多态性与冠状动脉粥样硬化性心脏病关系的研究  

Association of interleukin 10 gene --592C/A polymorphism with coronary artery disease

作　　者：金虎[1] 王燕[1] 徐力辛[1] 

机构地区：[1]浙江省温州医学院附属第一医院心血管内科,325027

出　　处：《中华医学遗传学杂志》2013年第6期724-728,共5页Chinese Journal of Medical Genetics

基　　金：浙江省温州市科技局项目（Y20090239）

摘　　要：目的研究白细胞介素10（interleukin10，IL10）基因-592C／A多态性与中国南方汉族人群冠状动脉粥样硬化性心脏病（简称冠心病）发病的相关性。方法采用基质辅助激光解吸电离飞行时间质谱技术对249例冠心病患者与132名无冠心病对照组人群儿加基因-592C／A位点（rs1800872）多态性检测，比较不同基因型和等位基因与冠心病患病风险的关系。结果IL10—592C／A位点基因型及等位基因在两组人群分布差异有统计学意义（P〈O．05），经Logistic回归分析校正-般临床资料差异后，发现A等位基因携带者（AA＋CA）患冠心病风险是非A等位基因携带者（CC）的2．449倍（95％CI：1．214～4．940，P=0．012）。结论基因-592C／A位点与冠心病发病的危险性相关，A等位基因可能是中国南方汉族人群冠心病发病的遗传危险因素之-。Objective To assess the association of interleukin 10 （ILIO）gene --592C/A polymorphism with morbidity of coronary heart disease in a southern Chinese Han population. Methods Frequencies of various genotypes and alleles for the 11.10 -- 592C/A polymorphism （rs1800872） were determined by the means of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry （MALDI-TOF-MS） in 249 patients and 132 unaffected controls. Results The frequencies of both 11.10 -- 592C/A site and different alleles have reached statistical significance （P 〈 0. 05 ） after correcting the difference in clinical data by logistic regression analysis. The risk of coronary heart disease in the patients with A gene （AAq-CA） was 2. 449 times greater than those without （95%CI：1. 214-4. 940, P=0. 012）. Conclusion II.10 gene --592C/A polymorphism is associated with the risk of coronary heart disease. Allele A may be a risk factor for this disease in the studied population.

关 键 词：冠状动脉粥样硬化性心脏病 白细胞介素10 -592C A位点 单核苷酸多态性 

分 类 号：R541.4[医药卫生—心血管疾病]