中国汉族人示指环指比例与冠心病的关系研究  

The Ratio of the Second to Fourth Digit Length and Coronary Artery Disease in Han Chinese Population

作　　者：王新本 周新春[1] 徐红 柴文慧 金明磊 姜礼红[5] 肖铁卉[6] 颜伟[6] 杨丁友[7] 吴天然[8] 

机构地区：[1]山东省荣成市人民医院,251000 [2]新疆维吾尔自治区乌鲁木齐市人民医院老年病科 [3]新疆维吾尔自治区昌吉市人民医院老年病科 [4]河北省承德市人民医院老年病科 [5]哈尔滨医科大学附属第二医院心内科 [6]中国人民解放军总医院老年心血管病研究所 [7]中国人民解放军总医院第一附属医院 [8]澳大利亚墨尔本大学生命科学院

出　　处：《医学研究杂志》2013年第11期75-77,共3页Journal of Medical Research

基　　金：吴阶平基金会临床科研专项基金资助项目(320.6750.1386)

摘　　要：目的示指无名指长度比(2D∶4D)和某些心脏疾病之间的关联有所报道,其与冠心病(CAD)的关系尚不明确。我们调查2D∶4D是否可以作为预测CAD的一个指标。方法本研究包括了884人,分为4组,221例CAD患者和221名健康对照。使用电子卡尺测量手指长度。t检验和Spearman相关系数用于检测2D∶4D组间的差异以及2D∶4D比值和CAD相关性。结果仅在男性观察到右手2D∶4D比例高于左手。在男性右手对照组和双手CAD组,2D∶4D比例均高于女性(P<0.001)。在男性CAD组,双手2D∶4D比值均高于男性对照组(P<0.001),但在女性没有观察到此趋势。各组2D∶4D比例和年龄之间没有显著关系(P>0.05,),在男性双手2D∶4D比例和CAD呈显著的正相关(P<0.001)。结论本研究表明在男性的双手2D∶4D比值和CAD之间存在显著相关。Abstract Objective The association between index finger to ring finger length ratio （2D： 4D） and cardiac disorders have been re- ported, however it has not been discussed in terms of coronary artery disease （CAD）. We investigated whether 2D： 4D could be used as a marker for predisposition to CAD as assessed by coronary angiography in Chinese men and women. Methods This study included 884 persons divided into 4 groups, 221 cases with CAD and 221 healthy persons without CAD as control in each sex group. Finger lengths were measured twice for both hands using electronic calipers. Student t test and the spearman correlation were used separately to detect the difference of 2D： 4D among groups and the relationship between 2D： 4D ratio and CAD. Results A significant higher 2D： 4D ratios be- tween right and left hand were observed only in men in both control and CAD groups. On the right hand in the control group and on both hands in the CAD group, the 2D： 4D ratios were higher in women than in men （P all 〈 0. 001 ）. In men with CAD, 2D： 4D were higher than men in control （ both hands, P 〈 0. 001 ） , but the trends were not observed in women. No relationship was founded between 2D： 4D ratios and age （P all 〉 0.05） , while a significant positive correlation between 2D： 4D ratios and CAD existed only in men in both hands （P 〈 0. 001 ）. There was no significant difference in age among the four groups. Conclusion The present study showed an association between 2D： 4D ratio and CAD on both hands in men.

关 键 词：中国汉族人 示指环指比例 冠心病 冠状动脉造影术诊断 

分 类 号：R541.4[医药卫生—心血管疾病]