曲安奈德耳后注射治疗主观性耳鸣疗效评价  

Effect of postaurical subcutaneously injection of triamcinolone acetonide for subjective tinnitus

作　　者：刁明芳[1] 孙建军[1] 田芳洁[1] 徐爽[1] 贾仲红[1] 刘阳[1] 陈东兰[1] 

机构地区：[1]海军总医院全军耳鼻咽喉科中心,北京100048

出　　处：《中华医学杂志》2013年第42期3384-3387,共4页National Medical Journal of China

摘　　要：目的 探讨耳后注射曲安奈德注射液对常规药物治疗无效的主观性耳鸣的疗效.方法 2012年5-11月,海军总医院耳科门诊100例主观性耳鸣成年患者,随机分为治疗组和对照组,每组50例.治疗组患者行耳后皮下注射曲安奈德注射液1 ml,对照组患者给予皮下注射生理盐水注射液1 ml,2组均每周注射1次,连续治疗5次.初诊和末次治疗后1周给予耳鸣严重程度评分.随访6个月.结果 两组主观性耳鸣治疗前的年龄、性别、耳鸣严重程度、耳鸣病程和听力损失程度差异均无统计学意义（P值分别为0.316、0.685、0.839、0.682、0.881）.治疗组50例主观性耳鸣患者中,显效8例,有效18例,无效24例,总体有效率为52%.对照组50例患者中,显效7例,有效15例,无效28例,总体有效率为44%.两组治疗有效率差异无统计学意义（P=0.724）.结论 耳后皮下注射曲安奈德治疗常规药物治疗无效的主观性耳鸣无明显效果.Objective To determine whether postaurical subcutaneous injection of triamcinolone acetonide is effective for subjective tinnitus refractory to medical treatment. Methods A total of 100 adult patients with subjective tinnitus of cochlear origin were randomly assigned to receive postaurical subcutaneous. Injection of either triamcinolone acetonide （ n = 50） or saline solution （ n = 50 ）. The treatment protocol comprised 5 injections, one per week for 5 weeks. Improvement was measured by tinnitus severity evaluation index evaluation scale, at baseline and one week after the last injection. The follow-up period was 6 months. Results No significant difference existed between two groups regarding age, gender, pure tone average, pretreatment tinnitus intensity, tinnitus duration or hearing loss level tinnitus duration （ P = 0. 316, 0. 685,0. 839,0. 682 and 0. 881 respectively）. No significant post-treatment changes in the tinnitus severity index（ experimental group = 52% , control group = 44% ） were observed in either group （ P = 0. 724 ）. The most frequently encountered side effect was pain during injection. Conclusion The postaurical subcutaneous injection of triamcinolone acetonide has no obvious benefit compared with placebo for subjective tinnitus of cochlear origin refractory to medical treatment.

关 键 词：耳鸣 曲安奈德 耳后皮下注射 

分 类 号：R764.45[医药卫生—耳鼻咽喉科]