钩吻素子的基本理化性质及其水溶液稳定性  

Studies on Physicochemical Proprieties of Koumine and Stability of Koumine Solution

作　　者：苏燕评[1] 石冬梅[2] 范振东[3] 廖凯君 俞昌喜[3] 

机构地区：[1]福建医科大学药学院药物化学系,福州350004 [2]福建医科大学药学院天然药物化学系,福州350004 [3]福建医科大学药学院药理学系,福州350004

出　　处：《福建医科大学学报》2013年第4期195-198,共4页Journal of Fujian Medical University

基　　金：福建省自然科学基金资助项目(2013J01374);福建省改革与发展委员会产业技术开发项目(闽发改投资[2009]958号);福建医科大学重大科研项目(09ZD009)

摘　　要：目的探讨钩吻素子的基本理化性质及其水溶液稳定性。方法高效液相色谱法测定钩吻素子在不同介质中的平衡溶解度和表观油／水分配系数；考察钩吻素子在不同pH水溶液、不同温度下的稳定性。结果钩吻素子在纯水中的平衡溶解度为141mg／mL，在碱性介质中的平衡溶解度降低；酸性条件下钩吻素子的表观油／水分配系数对数值LgP〈-1，碱性条件下LgP〉1；4℃和25℃时钩吻素子水溶液在pH3～9稳定性良好，37℃时在强酸（pH3）条件下稳定性较差。结论钩吻素子的水溶性较强，碱性条件下其亲脂性比酸性条件下高，高温条件下其强酸性水溶液稳定性较差。Objective To study the physicochemical proprieties of Koumine and the stability of Koumine solution. Methods High performance liquid chromatography （HPLC） are used to determine the equilibrium solubility and apparent oil/water partition coefficient of Koumine in different medium. The stability of Koumine solution was examined under the different pH and temperature. Results The equilibrium solubility of Koumine in water at 25 ℃ was 141 mg/mL and decreased in basic medium. The apparent oil/water partition coefficient LgP was n--1 in neural and basic condition, whereas LgP was ）1 in acidic condition. Between pH 3-9, the stability of Koumine solution was well sustained at 4 % and 25 ℃. However, the stability was significantly reduced under strong acidic condition （pH 3.0） at 37 ℃. Conclusion Koumine is highly soluble in water. It is more lipophilic in basic condition than in acidic condition. Under strong acidic and high temperature condition, the stability of Koumine is poor.

关 键 词：钩吻 钩吻素子 理化性质 平衡溶解度 表观油 水分配系数 稳定性 高效液相色谱 

分 类 号：R284[医药卫生—中药学]