福建省畲族人群单根据TSH水平来评定甲状腺功能异常患病率的调查  

The prevalence of thyroid dysfunction according to TSH level alone in She ethnic minority group of Fujian province

作　　者：吴娟[1] 林奉森 乔玉芳[2] 朱香清[2] 陈兆樵[2] 林丽香[3] 陈刚[3] 

机构地区：[1]福建医科大学省立临床医学院,厦门大学附属第一医院干部科,350003 [2]宁德市医院内分泌科 [3]福建省立医院内分泌科,福建医科大学省立临床医学院

出　　处：《中华内分泌代谢杂志》2013年第11期968-970,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：于2009年采用分层抽样的方法对福建省宁德市5523名畲族人群进行流行病学调查，最终5080名研究对象进入研究。该人群中甲状腺功能异常的患病率为12．1％，TSH低于正常范围者有124名（2．4％），高于正常范围者有491名（9．7％）。甲状腺过氧化物酶抗体（TPOAb）阳性率为10．8％（男性7．4％及女性13．5％，P〈0．01），TSH异常的人群中TPOAb阳性率较TSH正常者高。研究结果显示，TSH与TPOAb关系密切．在甲状腺功能亢讲及甲状腺功能减退人群中．自身免疫可能均起着萤要的作用。In 2009, 5 523 participants of She nationality living in Ningde City of Fujian province were multistage-stratified and randomly collected, and 5 080 were enrolled in analysis eventually. The TSH screening （reference range, 0.3-3.0 mIU/L） revealed biochemical hyperthyroidism in 2.4% （2. 1% of males and 2.7% of females） and biochemical hypothyroidism in 9.7 % （7.4% of males and 11.4% of females） of the participants. The prevalence of positive TPOAbs was 10.8% （7.4% of males and 13.5 % of females）. TSH values outside the normal reference range were associated with a higher prevalence of positive TPOAbs, indicating that autoimmunity seems to be an important factor in both hyperthyroidism and hypothyroidism.

关 键 词：畲族 甲状腺疾病 TSH 甲状腺过氧化物酶抗体 

分 类 号：R581[医药卫生—内分泌]