不同剂量辛伐他汀对STEMI患者PCI术后的影响  

Effects of Different Doses of Simvastatin on Patients with ST-segment Elevation Myocardial Infarction after Percutaneous Coronary Intervention

作　　者：宋颖[1] 于彦伟[1] 冯薇[1] 于阳[1] 李晶洁[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院心内二,哈尔滨市150001

出　　处：《中华全科医学》2013年第12期1843-1844,共2页Chinese Journal of General Practice

基　　金：黑龙江教育厅科学技术研究项目(11541170)

摘　　要：目的探讨术前不同剂量辛伐他汀对急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入治疗术(PCI)术后氧化应激水平和炎症的影响。方法采用随机双盲方法将患者分为治疗组和对照组。治疗组患者PCI术前给予40 mg辛伐他汀,对照组患者PCI术前给予20 mg辛伐他汀。比较两组患者术前和术后12 h的氧化应激水平和炎症反应。结果两组患者术前的氧化应激水平和炎症因子比较,差异无统计学意义(P>0.05);治疗组患者术后的NO(51.82±10.89)高于对照组患者(47.08±11.63);治疗组患者术后的ET-1[(4.42±1.08)ng/L]、IL-10[(15.02±5.58)ng/L]、Hs-CRP[(26.83±10.17)ng/L]低于对照组患者ET-1[(4.79±1.17)ng/L]、IL-10[(18.92±8.93)ng/L]、HsCRP[(32.16±10.65)ng/L]。结论术前给予40 mg辛伐他汀一次性负荷剂量对STEMI患者的治疗效果优于术前给予20 mg辛伐他汀。Objective To explore the effects of different doses of preoperative simvastatin on oxidative stress and inflammation in patients with ST-segment elevation myocardial infarction （STEMI） after percutaneous coronary intervention （PCI） operation. Methods The patients were divided into treatment group and control group by randomized double blind method. The patients in the treatment group were given 40 mg simvastatin before PCI operation, and the patients in the control group were given 20 mg simvastatin before PCI operation. The level of oxidative stress and inflammatory reaction of both groups before and after surgery（ 12 h later） were compared. Results The preoperative levels of oxidative stress and inflammatory of the two groups were compared,there was no significant difference（ P 〉 0.05 ） ;the NO level of treatment group after operation（ 51.82 ± 10.89 ） was higher than that of the control group （47.08 ± 11.63 ） ; the ET-1 of treatment group after operation [ （4.42 ± 1.08 ） , IL-10 （15.02± 5.58 ）, Hs-CRP （26.83 ± 10. 17 ） ] were lower than those of the control group [ （4.79 ± 1.17 ）, （ 18.92 ± 8.93 ） , （ 32.16 ± 10.65 ） ]. Conclusion The administration of preoperative 40 mg disposable loading dose of simvastatin should achieve an idea efficacy for STEMI patients.

关 键 词：心肌梗死 sT段抬高型 氧化应激 炎症因子 经皮冠状动脉介入治疗术 

分 类 号：R542.22[医药卫生—心血管疾病] R541.4[医药卫生—内科学]