急性颅脑创伤后垂体前叶激素变化及其相关因素  

Changes of Level of Anterior Pituitary Hormone after Craniocerebral Injury and Relative Factors

作　　者：骆实[1] 许小兵[1] 苏杭[1] 仇尔宁[1] 李子坚[1] 陈建民[1] 陈达良[1] 卢乐年[1] 

机构地区：[1]广东省佛山市顺德第一人民医院神经外科,528000

出　　处：《中华全科医学》2013年第12期1879-1880,共2页Chinese Journal of General Practice

基　　金：佛山市医学类科技攻关项目(201008190)

摘　　要：目的探讨颅脑损伤后患者的垂体前叶激素水平变化规律和颅脑损伤轻重分级的相关性,并探讨其对颅脑损伤预后的影响。方法回顾性分析67例颅脑损伤患者外伤后测得的垂体前叶激素水平,按照GCS积分分成轻型、中型、重型颅脑损伤组,并对所有患者随访半年。结果中、重型颅脑损伤急性期血清PRL、FT4含量显著升高,而LH、FSH、FT3含量显著降低;部分患者受伤72 h后及3月后复测,上述指标逐渐恢复正常。颅脑损伤病情稳定期垂体前叶激素的LH/FSH、GH、ACTH、TSH缺乏的发生率分别为25.0%、26.0%、7.8%和4.2%。结论颅脑损伤患者急性期内分泌功能有异常变化,垂体前叶激素水平与损伤轻重程度相关,与患者预后相关。Objective To study the plasma levels of anterior pituitary hormone in patients with different degree of craniocere- bral injury, and assess its effect on the prognosis of the patients. Methods The clinical data of 67 cases of craniocerebral injury were analyzed retrospectively. The plasma level of anterior pituitary hormone was tested after the injury. According to Glasgow Co- ma Scale（GCS） , the patients were divided into mild, moderate and severe craniocerebral injury groups. All the patients had a 6- month follow-up. Results In the acute period of moderate and severe craniocerebral trauma, the levels of PRL and FT4 were in- creased significantly, however, LH, FSH and Fr3 was decreased greatly. These data were close to normal after 72 hour and 3 months respectively in some of the patient. The prevalence of LH/FSH, GH, ACTH and TSH deficiency at the stable period were 25% ,26% ,7.8% and 4.2% ,respectively. Conclusion The levels of anterior pituitary hormone changed significantly and correlated to severity of the injury in the acute stage of the patients with craniocerebral trauma, which may be related to the prognosis of the patients.

关 键 词：颅脑损伤 垂体前叶激素 相关因素 

分 类 号：R651.15[医药卫生—外科学] R335.9[医药卫生—临床医学]