山莨菪碱对血栓性血小板减少性紫癜患者24小时尿蛋白定量的影响  

Effect of anisodamine on the variation of 24-hour protein excretion in patients with thrombotic thrombocytopenic purpura

作　　者：刘庆荣[1] 武英[2] 乌庆友 杨春华[1] 陈曦[1] 王欢[1] 褚金龙[1] 

机构地区：[1]河北医科大学附属唐山市工人医院血液科,河北省唐山063000 [2]河北联合大学公共卫生学院 [3]河北省抚宁县妇幼保健院

出　　处：《中国基层医药》2013年第23期3551-3552,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察山莨菪碱（Ani）联合血浆置换（PE）对血栓性血小板减少性紫癜（TTP）患者24h尿蛋白定量的影响。方法选择64例，TTP患者随机分为两组，每组32例。观察组予Ani联合PE治疗，对照组单用PE治疗，疗程均为21d。观察两组临床疗效，并于治疗后2、5、12、21d检查24h尿蛋白定量。结果两组治疗21d后24h尿蛋白均下降，其中观察组在治疗后2、5、12d与对照组差异均有统计学意义（均P〈0．05）；两组第21天尿蛋白定量差异无统计学意义（P〉0．05）。治疗21d后，观察组有效率97％，对照组有效率81％，两组差异有统计学意义（P〈0．05）。结论山莨菪碱联合血浆置换能更有效治疗TTP。Objective To observe the effect of plasma exchange（PE） combined with anisodamine on the variation of 24-hour protein excretion in patients with thrombotic tbrombocytopenic purpura（TIP）. Methods 64 pa- tients with TTP were randomly divided into two groups, each group contained 32 patients. The treatment group was giv- en anisodamine injection combined with PE, while the control group was just given PE ,with a same course of 21 days duration. The efficacy of two groups was observed, and 24-hour protein excretion was recorded 2,5,12,21 days after treatment. Results After treatment for 21 days ,24-hour protein excretion in both two groups was decreased, that in treatment group 2,5 and 12 days after treatment was lower than control group, there were significant differences （P 〈 0.05）. But no significant difference between the two groups was found 21 days after treatment （P 〉 0.05 ）. After treatment for 21 days, the effective rate of the treatment group was 97%, that of the control group was 81%, the differ- ence was significant （ P 〈 0.05 ）. Conclusion Anisodamine combined with PE shows more effective in treatment of TIP.

关 键 词：紫癜 血栓性血小板减少性 24H尿蛋白定量 血浆置换 山莨菪碱 

分 类 号：R554.6[医药卫生—血液循环系统疾病]