2型糖尿病家系一级亲属代谢综合征危险因素的分析  

Analysis of Risk Factors for Metabolic Sydrome in the First Degree Relatives of Type 2 Diabetes Patients

作　　者：周慧[1,2] 吴振[1,2] 周素娴[1,2] 韦晓谋[1,2] 邓婷婷[1,2] 韦卉[1,2] 李锦华[1,2] 

机构地区：[1]广西医科大学第四附属医院 [2]柳州市工人医院内分泌科,柳州545005

出　　处：《中国医药导刊》2013年第10期1633-1634,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:分析2型糖尿病家系一级亲属同胞的代谢综合征发病率及各危险因素情况。方法:以41个2型糖尿病家系中同胞一级亲属为研究组(n=98),以同胞配偶中无糖尿病家族史的一级亲属同胞为对照组(n=85)。测定身高、腰围、体重、血压、空腹血糖、餐后2小时血糖、甘油三酯、高密度脂蛋白胆固醇,非糖尿病者行口服葡萄糖耐量试验。结果:2型糖尿病家系一级亲属同胞的代谢综合征的患病率(32.65%),显著高于无糖尿病家族史的一级亲属同胞(12.94%)χ2=9.8365 P<0.01。中心性肥胖、糖尿病家族史、糖尿病、高血压、血脂异常与代谢综合征密切相关(均P<0.05)。结论:2型糖尿病家系一级亲属是代谢综合征的高危人群。中心性肥胖、糖尿病家族史、糖尿病、高血压、高甘油三酯血症、高密度脂蛋白胆固醇降低是代谢综合征的重要危险因素。Objective：To analyse the incidence rate and risk factors of metabolic sydrome in the first degree relatives of type 2 diabetes patients. Methods：First degree relatives of type 2 diabetes patients from 41 diabetes mellitus pedigree were selected as study group（n=98）,and first degree relatives without diabetes familial history of their spouses were selected as control group（n=85）.High、waist circumference、weight、blood pressure、fasting and 2-hour postprandial blood glucose,tirglyceride,high dersity lipoprotein-cholesterol were measured in two groups,OGTT were measured in those without diabetes.Results：The incidence rate（32.65%） of metabolic sydrome in the first degree relatives of type 2 diabetes patients was significantly higher than that of the first degree relatives of healthy people（12.94%）χ2=9.8365,P〈0.01.Central obesity、the familial history of type2 diabetes、diabetes mellitus、hipertension、dyslipidemia was closely related to metabolic sydrome. Conclusion：First degree relatives of type 2 diabetes patients are the high risk populations of metabolic sydrome.central obesity、the familial history of type2 diabetes、diabetes mellitus、hypertension、hyper-tirglyceridemia,low level of high dersity lipoprotein-cholesterol are the high risk factors of metabolic sydrome.

关 键 词：糖尿病2型 代谢综合征 危险因素 

分 类 号：R587.1[医药卫生—内分泌]