壳聚糖异相接枝L-谷氨酸甲酯的合成研究  

Synthesis of Chitosan Heterogeneously Grafted by Methyl L-Glutamate

作　　者：冯芳[1] 谭锦[1] 刘预[2] 赵斌元[2] 胡克鳌[2] 

机构地区：[1]苏州科技学院化学生物与材料工程学院,江苏省环境功能材料重点实验室,苏州215009 [2]上海交通大学金属基复合材料国家重点实验室,上海200030

出　　处：《材料导报》2013年第20期90-94,共5页Materials Reports

基　　金：上海市自然科学基金(04ZR14087);江苏高校优势学科建设工程资助项目;苏州科技学院科研基金(XKY201024)

摘　　要：在乙酸乙酯溶剂的异相条件下,以壳聚糖的氨基引发N-羧酸酐(NCA)开环聚合,制备了接枝L-谷氨酸甲酯壳聚糖产物。异相接枝反应中,增加NCA的用量和适当延长反应时间,可提高谷氨酸甲酯接枝侧链聚合度。IR、CP/MAS-13 CNMR结果表明,谷氨酸甲酯侧链通过酰胺键与壳聚糖结合,形成梳状接枝产物。XRD和DSC、TG/DTG测试发现,接入谷氨酸甲酯侧链引起的异相接枝物的结构谱图和热稳定性较原料有明显改变,反映了壳聚糖接枝产物结构和接枝量的差异性。反应体系有利于壳聚糖材料的表面接枝改性氨基酸,赋予材料独特的生物活性。Graft polymers based on chitosan covalently linked polypeptide chains at some ot the amino groupb were prepared by graft eopolymerization of 3,-methyl L-glutamate N-carboxy anhydride（NCA） onto chitosan using eth- yl acetate solvent heterogeneous system. In this heterogeneous reaction, the length of the grafted side chains of methyl L-glutamate increased with the increasing amount of NCA and the reaction time. IR and CP/MAS-la CNMR results showed that the methyl L-glutamate side chains were bonded with chitosan through amide bond to form comb-like graft products. XRD spectrum and DSC, TG/DTG testing illustrated that the structure and thermal stability of hete- rogeneous graft products gave significant changes, which was the results of main chain structure changes of chitosan caused by the grafted side chains and reflected each chitosan graft product has different structure and the grafting num- ber. Novel reaction system are considered to be useful for surface grafting modification of amino acid on chitosan, im- parting materials special bioactive properties.

关 键 词：壳聚糖 L-谷氨酸甲酯 异相接枝 开环聚合 

分 类 号：TB324[一般工业技术—材料科学与工程] O636[理学—高分子化学]