CA125和NT-proBNP水平在慢性心衰中的比较及临床意义  

Comparison of serum CA125 and NT- proBNP levels and their clinical significance in patients with chronic heart failure

作　　者：王芳[1] 朱杰[1] 王丽娟[2] 沈月爽[1] 范芳华[1] 

机构地区：[1]浙江医院检验科,浙江杭州310007 [2]浙江医院心内科,浙江杭州310007

出　　处：《中国卫生检验杂志》2013年第16期3232-3234,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨血清CA125的变化在慢性心衰患者的临床诊断、预后评估中的临床意义。方法用免疫发光法检测健康对照组和慢性心衰患者CRT治疗前后的糖类四项抗原和proBNP的血清水平。结果经统计分析,与健康人群相比较,NT-proBNP、IL-6和CA125显著增高。但是CA199、CA153、CA724在两组间差别无统计学意义。CA125与NT-proBNP(r=0.401,P=0.036)在慢性心衰组中呈明显正相关;与治疗前相比,治疗后慢性心衰患者的NT-proBNP和CA125显著降低(P<0.01),但是糖类抗原CA199、CA153、CA724在治疗前后无显著差别。同时心衰患者血清CA125水平与LVEDD、LVEF有明显相关性(r分别为0.57和-0.54,均为P<0.01)。结论 CA125血清水平在慢性心衰患者的诊断、预后评估中有着重要意义。Objective To evaluate the change and significance of serum CA125 level in diagnosis and prognosis of patients with chronic heart failure. Methods Immune luminescence method was used to measure the serum levels of carbohydrate antigens and proBNP in patients with chronic heart failure and healthy controls. Results After statistical analysis, the serum levels of IL -6, NT- proBNP and CA125 were significantly higher compared with healthy controls. But CA199, CA153, CA724 had no significant difference between the two groups. CA125 was significantly positively correlated with NT - proBNP （r = 0.401, P = 0.036） in chronic heart failure group. Compared with those before treatment, the levels of NT - proBNP and CA125 in patients were significantly lower after treatment（P 〈 O. 01 ）, but serum CA199, CA153, CA724 levels had no significant difference be- fore and after treatment. Correlation analysis showed that serum CA125 level was significantly correlated with LVEDD and LVEF in heart failure patients （ r were 0.57 and - 0.54, all P 〈 0.01 ）. Conclusion CA125 level is of great significance in diagno- sis and prognosis evaluation of patients with chronic heart failure.

关 键 词：CA125 NT-PROBNP 慢性心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]