阿托伐他汀对心力衰竭患者心功能的影响  

Effect of atorvastatin on cardiac function in patients with heart failure

作　　者：沈桂彬[1] 张丽华[2] 

机构地区：[1]郑州市第七人民医院,郑州450016 [2]郑州大学第二附属医院心血管内科

出　　处：《临床医学》2013年第8期18-19,共2页Clinical Medicine

摘　　要：目的观察阿托伐他汀对心力衰竭患者心功能的影响。方法将66例心力衰竭患者随机分为对照组和治疗组(阿托伐他汀组),在治疗前和治疗后2个月评价NHYA心功能,心脏彩超测定左室射血分数(LVEF)、左室舒张末期内径(LVEDD),测定血浆N末端脑利钠肽(NT-proBNP)及C-反应蛋白(CRP)水平。结果与对照组治疗后相比,阿托伐他汀组NYHA心功能分级下降,NT-proBNP及CRP水平下降,LVEF增加及LVEDD降低。结论阿托伐他汀通过抑制心脏重构、减轻炎症反应而对心力衰竭患者有益。Objective To observe the effect of atorvastatin on cardiac function in patients with heart failure. Methods Six- ty-six patients with heart failure were randomly divided into control group and treatment group （atorvastatin group）, NHYA cardi- ac function, echocardiography determination of left ventricular ejection fraction （LVEF） , left ventricular end-diastolic diameter （LVEDD） were evaluated and plasma N-terminal brain natriuretic peptide （NT-proBNP） and C-reactive protein （CRP） levels were determined before treatment and two months after treatment. Results Compared with the control group after treatment, NY- HA cardiac function grade decline, NT-proBNP and CRP level decreased and LVEF increased and LVEDD reduction in treatment group. Conclusion Atorvastatin benefit patients with heart failure by reducing the inflammatory response and inhibiting cardiac remodeling.

关 键 词：阿托伐他汀 血浆N末端脑利钠肽 C-反应蛋白 心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]