黑面神根部化学成分的研究  

Chemical constituents from roots of Breynia fruticosa

作　　者：林理根[1,2] 柯昌强[1] 叶阳[1] 

机构地区：[1]中国科学院上海药物研究所新药研究国家重点实验室,上海201203 [2]澳门大学中华医药研究院中药质量研究国家重点实验室

出　　处：《中草药》2013年第22期3119-3122,共4页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(30123005);科技部基金资助项目(2004CB518902);澳门大学基金资助项目(SRG2013-00038-ICMS-QRCM)

摘　　要：目的研究山漆茎属植物黑面神Breynia fruticosa根的化学成分。方法利用硅胶柱色谱和Sephadex LH-20等色谱方法进行分离纯化,应用NMR等方法鉴定结构。结果从黑面神根95%乙醇冷浸液的醋酸乙酯部位分离鉴定了13个化合物,其中包括4个三萜类化合物:无羁萜(1)、木栓醇(2)、羽扇烯酮(3)和算盘子二醇(4);3个甾醇类化合物:β-谷甾醇(5)、豆甾烷-3β,6β-二醇(6)和β-sitosterylglucoside-6′-octadecanoate(7);2个脑苷类化合物:1-O-β-D-glucopyranosyl-(2S,3R,4E,8Z)-2-[(2-hydroxyoctadecanoyl)amido]-4,8-octadecadiene-1,3-diol(8)和1-O-β-D-glucopyranosyl-(2S,3S,4R,8Z)-2-[(2R)-2-hydroxypentacosanoylamino]-8-octadecene-1,3,4-triol(9);4个其他类化合物:()-表儿茶素(10)、ε-己内酯(11)、aviculin(12)和香草醛(13)。结论化合物3、4、6～9和11为首次从山漆茎属植物中分离得到,其中化合物11为首次从天然产物中分离得到。Objective To study the chemical constituents from the roots of Breynia fruticosa. Methods The compounds were isolated by comprehensive column chromatography, and the structures were elucidated by spectral methods. Results Thirteen compounds were isolated and elucidated, including four triterpenoids, friedelin （1）, friedelinol （2）, lupenone （3）, and glochidiol （4）; three steroids, including β-sitosterol （5）, stigmastane-3β, 6β-diol （6）, and 13-sitosterylglucoside-6＇-octadecanoate （7）; two cerebrosides, including 1-O-β-D-glucopyranosyl-（2S, 3R, 4E, 8Z）-2-[（2-hydroxyoctadecanoyl） amidol-4, 8-octadecadiene-1, 3-diol （8） and 1-O-β-D-glucopyranosyl-（2S, 3S, 4R, 8Z）-2-[（2R）-2-hydroxypentacosanoylamino]-8-octadecene-1, 3, 4-triol （9）; and four other compounds, including （-）-epicatchin （10）, e-caprolactone （11）, aviculin （12）, and vanillin （13）. Conclusion Compounds 3, 4, 6--9, and 11 are isolated from the plant ofBreynia J. R. et G. Forst. nom. cons. for the first time, and compound 11 is isolated from the natural product for the first time.

关 键 词：山漆茎属 黑面神 算盘子二醇 豆甾烷-3β 6β-二醇 Ε-己内酯 

分 类 号：R284.1[医药卫生—中药学]