大果榕根的化学成分研究  

Chemical constituents from roots of Ficus auriculata

作　　者：祁翠翠[1] 陈光英[1] 陈文豪[1] 宋小平[1] 韩长日[1] 

机构地区：[1]海南师范大学化学与化工学院热带药用植物化学教育部重点实验室,海南海口571127

出　　处：《中草药》2013年第22期3127-3130,共4页Chinese Traditional and Herbal Drugs

基　　金：973计划前期研究专项课题(2011CB512010);国家自然科学基金项目(81160391;21166009)

摘　　要：目的对大果榕Ficus auriculata根的化学成分进行研究。方法采用正、反相硅胶色谱、凝胶色谱及重结晶等方法进行分离纯化,根据波谱数据及理化性质鉴定化合物结构。结果从大果榕根95%乙醇冷浸提取物的醋酸乙酯部位分离得到13个化合物,分别鉴定为β-谷甾醇(1)、α-香树脂醇(2)、6β-羟基-豆甾-4-烯-3-酮(3)、豆甾烷-3,6-二酮(4)、豆甾-7,22-二烯-3β,5α,6β-三醇(5)、3-(1-羟乙基)-7-羟基异苯并呋喃酮(6)、(R)-(+)-de-O-methyllasiodiplodin(7)、前胡醇(8)、()-3,5-dimethyl-8-methoxy-3,4-dihydroisocoumarin(9)、(R)-()-mellein methyl ethe(r10)、5-formyl-8-hydroxy-3,4-dihydroisocoumarin(11)、(R)-()-5-methoxycarbonyl mellein(12)、β-胡萝卜苷(13)。结论除化合物1外,所有化合物均为首次从大果榕中分离得到,其中化合物4～12为首次从榕属植物中分离得到。Objective To study the chemical constituents from the roots ofFicus auriculata. Methods The chemical constituents were isolated and purified by various chromatographic methods, including silica gel, ODS, Sephadex LH-20 columns, and recrystallization. Structures of the isolated compounds were elucidated based on NMR and ESI-MS data, as well as physicochemical properties. Results Thirteen compounds were obtained in the EtOAc fraction of ethanol extract from the roots of F. auriculata and identified as β-sitosterol （1）, α-amyrin （2）, 6β-hydroxystigmast-4-en-3one （3）, stigmasta-3, 6-dione （4）, （22E, 24S）-24-methyl-5a- choleata-7, 22-diene-313, 5, 613-triol （5）, 3-（l-hydroxyethyl）-7-hydroxy-l-isobenzofuranone （6）, （R）-（＋）-de-O-methyllasiodiplodin （7）, decursinol （8）, （-）-3, 5-dimethyl-8-methoxy-3, 4-dihydroisocoumarin （9）, （R）-（-）-mellein methyl ether （10）, 5-formyl-8-hydroxy-3, 4-dihydroisocoumarin （11）, （R）-（-）-5-methoxycarbonyl mellein （12）, and 13-daucosterol （13）. Conclusion All the compounds except compound 1 are firstly isolated from E auriculata, and compounds 4--12 are found in the plants ofFicus Linn. for the first time.

关 键 词：大果榕 榕属 α-香树脂醇 豆甾-7 22-二烯-3β 5α 6β-三醇 前胡醇 

分 类 号：R284.1[医药卫生—中药学]