低CD_4^+T淋巴细胞计数艾滋病患者巨细胞病毒检测分析  

Cytomegalovirus detection rate in AIDS patients with low CD_4^+ T cell count

作　　者：何太雯[1] 杨娅玲[1] 张璐[2] 王宏萍[2] 张仁芳[3] 沈银忠[3] 刘莉[3] 郑毓芳[3] 卢洪洲[3] 

机构地区：[1]上海市公共卫生临床中心眼科,201508 [2]上海市公共卫生临床中心临床流行病学部 [3]上海市公共卫生临床中心感染科

出　　处：《中国公共卫生》2013年第12期1745-1747,共3页Chinese Journal of Public Health

基　　金：国家“十二五”传染病重大专项(2012ZX10001-003)

摘　　要：目的了解艾滋病(acquired immunodeficiency syndrome,AIDS)患者巨细胞病毒(cytomegalovirus,CMV)感染情况及与CD+4T淋巴细胞、患者年龄、性别等关系。方法对2006年11月—2011年2月上海市公共卫生临床中心收治的处于III^IV期的291例AIDS住院患者经抗逆转录病毒治疗前的血液样本进行CMV检测、CD+4T淋巴细胞计数,分析其与年龄、性别的关系。结果 CMV DNA在AIDS患者中检出阳性率为51.55%,CMV pp65抗原阳性率为19.91%;CMV检出率与患者CD+4T淋巴细胞数量呈负相关(χ2=42.349,P=0.000);男性CMV DNA阳性率为53.82%,女性为38.10%,二者差异有统计学意义(χ2=3.556,P=0.043)。结论低CD+4T淋巴细胞计数AIDS人群中CMV检出率较高,检出率及病毒载量均与CD+4T淋巴细胞计数呈负相关,男性检出率高于女性。Objective To explore the relationships between cytomegalovirus（CMV）infection and CD4＋ T cell count,age,and gender in AIDS patients.Methods Blood samples of 291 AIDS patients hospitalized in a medical center in Shanghai,China were tested for CMV DNA,CMV pp65 antigen,and CD4＋ T cell count.The information on age and gender were collected.Results CMV DNA was detected in 51.55% of the AIDS patients and the positive rate of CMV pp65 antigen was 19.91%.Median CMV viral load of CMV DNA-positive patients was between 3 810 copies/mL and 20 825.5 copies/mL.CMV detection rate was significantly different in subgroups stratified by CD4＋ T cell count（χ2=42.349,P=0.000）.The rate of CMV DNA-positive in the male patients was 53.82%,and the rate in the female patients was 38.10%（χ2=3.556,P=0.043）.Conclusion AIDS patients with low CD4＋ T cell counts have an increased susceptibility to CMV infection.Both CMV DNA-positive rate and viral load increase significantly with the reduction of CD4＋ T cell count.CMV infection rate in male AIDS patients is significantly higher than that in female AIDS patients.

关 键 词：巨细胞病毒感染 艾滋病 PP65抗原 CD4+淋巴细胞 

分 类 号：R512.91[医药卫生—内科学]