复方中药组分对糖尿病大鼠肾脏保护作用  

Protective effect of compound traditional Chinese medicine components on kidney in diabetic rats

作　　者：刘文艳[1] 刘晓舒[1] 马越娇[1] 韩健[1] 曲志成[2] 高普[2] 宋光熠[1] 

机构地区：[1]辽宁省基础医学研究所药理研究室,辽宁沈阳110101 [2]中国中医科学院西苑医院老年医疗中心

出　　处：《中国公共卫生》2013年第12期1788-1789,共2页Chinese Journal of Public Health

基　　金：国家自然科学基金(81173617)

摘　　要：目的探讨复方中药组分防治糖尿病及糖尿病肾病的有效性及其作用机制。方法应用链尿菌素复制大鼠糖尿病模型,实验设模型组、复方中药高、中、低剂量组和阳性对照组(二甲双胍),观察肾功能相关的指标改变。结果与模型组比较,复方中药高剂量组大鼠血糖[(6.68±2.39)mmol/L]、血清尿素氮[(10.47±2.09)mmol/L]、血浆肌酐[(57.24±11.53)μmol/L]、尿蛋白[(33.51±12.11)mg/d]明显下降,肾脏Caspase-3表达降低,肾脏中钠钾ATP酶活性升高。结论复方中药组分可降低糖尿病大鼠血糖、改善肾脏功能,对糖尿病大鼠肾脏具有一定保护作用。Objective To confirm the effect and mechanism of compound traditional Chinese medicine components on prevention and treatment of diabetes and diabetic nephropathy.Methods Intraperitoneal injection of streptozocin（0.055 mg/g）was used to establish diabetes rat model;an experimental model group,high-,medium-,and low-compound traditional Chinese medicine groups,and a positive control group（metformin）were also established.Then a number of related indicators of renal functions were measured.Results The compound traditional Chinese medicine component showed a definite hypoglycemic effects,and reduced levels of blood urine nitrogen（BUN）,plasma creatinine（Cr）,caspase-3,urine protein（UP）and increased Na＋,K＋-ATPase of kidney were observed.Conclusion The compound traditional Chinese medicine components can prevent and treat diabetic nephropathy via inhibiting the apoptosis and improving renal function in diabetic rats.

关 键 词：复方中药组分 肾功能 糖尿病肾病(DN) 

分 类 号：R587.1[医药卫生—内分泌]