肺功能检测在慢性阻塞性肺疾病诊断中的意义  

Significance of pulmonary function testing in the diagnosis of chronic obstructive pulmonary disease

作　　者：黄立搜[1] 刘文兵[1] 徐慧连[1] 丁学军[1] 楼黎明[1] 

机构地区：[1]浙江中医药大学附属第三医院呼吸内科,杭州310005

出　　处：《国际呼吸杂志》2013年第23期1779-1781,共3页International Journal of Respiration

基　　金：浙江中医药大学校级基金（2011ZY18）;浙江中医药大学附属第三医院院级基金（ZS11CA11）

摘　　要：目的探讨肺功能检测在慢性阻塞性肺疾病（COPD）诊断中的意义。方法通过对60例COPD患者的肺功能进行检测，并与74例正常人进行对照，观察COPD患者肺功能的特点。结果COPD轻度、中度、重度和极重度的比例分别为23．7％、42．4％、25．4％和8．5％，并且4组之间的百分比、男女比例、年龄差异均无统计学意义（P〉0．05）。除COPD轻度与对照组的FEV，％pred差异无统计学意义（P〉0．05）外，COPD轻度、中度、重度和极重度与对照组的FEV1％pred、FEV1／FVC、DLCO和DLCO／VA差异均有统计学意义（P〈0．05）。COPD轻度、中度、重度和极重度4组FEV，％pred随COPD的严重程度逐渐降低，且组间比较差异有统计学意义（P〈0．05）。COPD患者肺功能各指标FEV1、FEV1／FVC、DLCO、DLCO／VA间均有良好的相关性（P〈0．05）。结论COPD患者FEV1、FEV1／FVC、DLCO、DLCO／VA较正常健康人降低，其肺通气功能和肺弥散功能具有良好的相关性，提示肺功能检测在COPD诊断中具有非常重要的临床意义，应予积极推广。Objective To explore the significance of pulmonary function testing in the diagnosis of chronic obstructive pulmonary disease（COPD）. Methods Sixty patients with COPD for lung fun6tion testing while 74 cases of normal controls to observe the characteristics of pulmonary function of patients with COPD. Results The proportion of mild, moderate, severe and very severe of COPD patients was 23.7%, 42.4 %, 25.4% and 8.5%, and the percentage difference among the four groups, male to female ratio differences, age differences were not statistically significant （ P 〉 0.05）. The FEV1%pred, FEV1/ FVC,DLCO and DLCO/VA of the mild, moderate, severe and very severe of COPD patients were significantly lower than the control group （ P 〈0.05）, except the FEV1%pred of mild of COPD （ P 〉0.05）. The FEV1 %pred of mild, moderate, severe and very severe of COPD decreased with the severity of COPD, coparation between each two groups were statistically significant （ P 〈0.05）. There is a good correlation between each lung function index, such as FEV1, FEV1/FVC, DLCO and DLCO/VA of COPD patients（ P 〈.05）. Conclusions The FEV1, FEV1/FVC, DLCO, DLCO/VA of patients with COPD were lower than normal healthy people, their pulmonary ventilation function and pulmonary diffusion function had a good correlation, suggesting that lung function testing in the diagnosis of COPD had a very important clinical significance, and should be actively promoted.

关 键 词：慢性阻塞性肺疾病 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]