长期吸入布地奈德／福莫特罗联合体位引流对稳定期支气管扩张患者生存质量的影响  

Effect of long-term inhaled budesonide/formoterol combined with postural drainage QOL in patients with stable bronchiectasis

作　　者：谢衬梨[1] 赵一菊[1] 梁秋亭 李朝霞[1] 

机构地区：[1]东莞市太平人民医院呼吸科,523900

出　　处：《国际呼吸杂志》2013年第23期1793-1796,共4页International Journal of Respiration

摘　　要：目的观察长期吸人布地奈德／福莫特罗联合体位引流预防支气管扩张再感染的临床疗效及生存质量的评价。方法69例确诊为支气管扩张症的患者在经过急性期治疗、病情得到控制后，随机双盲对照方法，分为2组并进行12个月的维持治疗。对照组单纯体位引流，治疗组吸人布地奈德／福莫特罗的同时体位引流。观察患者的临床症状、呼吸困难评分、肺功能变化、急性发作频率及生存质量评分。结果有2例患者因大咯血行手术治疗退出本试验，有1例患者因呼吸衰竭退出本试验，66例完成研究。长期体位引流能够改善支气管扩张症患者的咳嗽咳痰的临床症状，但未能改善患者呼吸困难症状、肺功能、急性发作次数和生存质量，吸人布地奈德／福莫特罗与体位引流联合使用时，能够改善支气管扩张症患者的咳嗽咳痰的临床及呼吸困难症状，能减少急性发作次数，并可在一定程度上改善肺功能指标，提高患者生存质量。结论长期吸人糖皮质激素／β受体激动剂联合体位引流对支气管扩张症有较好的临床效果，可减轻患者的症状并减少急性发作次数，改善肺功能，提高患者生存质量，能够作为长期治疗支气管扩张症的一种选择。Objective To observe the long-term inhaled budesonide/formoterol combined with postural drainage in patients with bronehiectasis prevention bronchiectasis reinfection clinical curative effect and life quality evaluation. Methods Sixty-nine cases patients with bronchiectasis after exacerbation and maintained stable were randomly double-blind divided into two groups and 12 months of maintenance therapy. Control group simple postural drainage, treatment group inhaled budesonide/ formoterol,at the same time Postural drainage. Observation of patients with clinical symptoms, dyspnea scale, pulmonary function changes, acute seizure frequency and quality of life score. Results Two patients with big haemoptysis surgical treatment exit our test, one patient with respiratory failure exit our test,66 patients completed the study. The results showed that long-term position drainage can improve the clinical symptoms with bronchiectasis, whille failed to improve dyspnea in patients with symptoms, pulmonary function, the frequency of exacerbation and survival quality, inhalation budesonide/formoterol combined postural drainage can improve the clinical symptoms and dyspnea, can reduce the frequency of exacerbation in patients, and in a certain extent improve lung function index, and improve the patients quality of life. Conclusions Long-term inhaled glucocorticoid/beta receptor agonist combined postural drainage to hronchieetasis had good clinical effect, can reduce the symptoms of patients and decrease the frequency of exacerbation in patients, improve lung function with bronchiectasis. It may be as an alternative to the maintenance treatment of bronchiectasis.

关 键 词：支气管扩张症 吸入性糖皮质激素 Β受体激动剂 体位引流 

分 类 号：R562.2[医药卫生—呼吸系统]