止痛胶囊对大鼠镇痛作用的实验研究  

EXPERIMENTAL STUDY OF ANALGESIC EFFECT ON HAMSTER WITH ZHENTONG JIAONANG AND ITS MECHANISM

作　　者：刘延庆[1] 朱健泉[2] 薛永骥[1] 郭试瑜[3] 久光正[3] 

机构地区：[1]扬州大学医学院,扬州225001 [2]扬州大学医学院附属医院,扬州225001 [3]日本昭和大学医学部

出　　处：《江苏临床医学杂志》2000年第6期455-456,459,共3页Journal of Jiangsu Clinical Medicine

基　　金：江苏省科委立项资助项目

摘　　要：目的 :探讨止痛胶囊对于大鼠的镇痛作用及其机理。方法 :采用光热刺激鼠尾—逃避法 (Tailflicktest)测定大鼠痛阈。结果 :止痛胶囊能剂量依赖性地提高大鼠光热刺激鼠尾—逃避法的痛阈 ;纳洛酮能部分翻转止痛胶囊的镇痛作用。结论 :止痛胶囊具有镇痛作用 。Objective:To inquire into the analgesic effect on hamster with ZHENTONG JIAONANG (pain-alleviated capsule) and its mechanism. Method:Tail flick test was used to determinate pain thresholds of hamster.Results: ①ZHENTONG JIAONANG could raise thresholds of hamster dependently by method of tail flick test;②Naloxone could partly bend back analgesic effect of ZHENTONG JIAONANG.Conclusion:ZHENTONG JIAONANG has the analgesic effect which is probably related to opium receptor.

关 键 词：中药 光热刺激鼠尾-逃避法 止痛胶囊 大鼠 

分 类 号：R285.5[医药卫生—中药学] R441.1[医药卫生—中医学]