甲状腺功能检查对原发性甲亢诊断的价值比较  

Comparison of The Sensitivity and Specificity of Thyroid Function Tests for The Diagnosis of Primary Hyperthyroidism

作　　者：黄玉萍[1] 李光明[1] 顾明君[2] 沈玉美[2] 戴士冕 杨鲁渤 

机构地区：[1]武警上海总队医院,上海201103 [2]第二军医大学附属长征医院内分泌科,上海200003

出　　处：《标记免疫分析与临床》2000年第4期189-192,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：研究各项甲状腺功能检查在原发性甲亢诊断中的意义。 1997年 4月至 1998年 10月在长征医院内分泌门诊就诊的被怀疑患原发性甲亢的 2 2 8人 ,于上午空腹时静脉采血 ,测定其血清TT3、TT4 、FT3、FT4 、超敏TSH。根据临床表现及实验室检查 ,这 2 2 8人中有 68人确诊为患原发性甲亢。TT3、TT4 、FT3、FT4 、超敏TSH在各自最佳截断点 (cut -off -point)时敏感度及特异度分别为 :TT3≥ 2 .0 5ng/mL时 ,敏感度为 77.94 % ,特异度为 72 .50 % ;TT4 ≥ 12 0ng/mL时 ,敏感度为 76.4 7% ,特异度为71.88% ;FT3≥ 3.92pg/mL时 ,敏感度为 85.2 9% ,特异度为 86.2 5% ;FT4 ≥ 15.0pg/mL时 ,敏感度为92 .65% ,特异度为 93.13% ;超敏TSH≤ 5.4 μIU/mL时 ,敏感度为98.53% ,特异度为 96.2 5%。在原发性甲亢诊断中 ,各项检查敏感度及特异度由高到低依次为超敏TSH、FT4 、FT3、TT3、TT4 。The article is to investigate the sensitivity and specificity of thyroid function tests for the diagnosis of primary hyperthyroidism. The study was performed at the outpatient endocrine clinic of the Changzheng Hospital from April 1997 to October 1998. Serum TT 3,TT 4,FT 3,FT 4and S-TSH were assayed in 228 patients with suspected hyperthyroidism. In diagnosing primary hyperthyroidism, the sensitivity and specificity of TT 3, TT 4, FT 3, FT 4 and S-TSH in cut-off-point were showed in following, respectively: at TT 3≥2.05ng/mL,77.94%,72.50%;at TT 4≥120.0ng/mL, 76.47%, 71.88%; at FT 3≥3.92pg/mL,85.29%,86.25%; at FT 4≥ 15.0 pg/mL,92.65%, 93.13%; and at S-TSH≤5.4μIU/mL,98.53%, 96.25%. It is concluded that S-TSH is more sensitive and specific than others for the diagnosis of primary hyperthyroidism.

关 键 词：原发性甲亢 甲状腺功能检查 敏感度 特异度 

分 类 号：R581.104[医药卫生—内分泌]