改进的小鼠颈部心脏移植模型的制作  

Improved Technique of Cervical Heart Transplantation Model in Mice

作　　者：王铭辉[1] 付鉴[1] 宋尔卫[1] 孙培吾 

机构地区：[1]中山医科大学孙逸仙纪念医院心脏外科,广州510120

出　　处：《现代临床医学生物工程学杂志》2000年第4期259-260,共2页Journal of Modern Clinical Medical Bioengineering

摘　　要：目的　探制小鼠颈部心脏移植模型手术技术的改进 .方法　采用供心主动脉与受体颈总动脉侧壁长度相近的切口行端—侧连续吻合的方法进行 40次小鼠颈部心脏移植 .结果　应用该方法使供心总缺血时间缩短至 30分钟 ;7天存活率提高到 97% .结论　新技术的采用降低了小鼠颈部心脏移植模型制作的难度 ,是一种简单实用的新方法 .Objective To develop a model of mouse cervical heart transplantation by using new improved techniques.Method The aorta of the domor heart and the right common carotid artery of the recipient were anastomosed using the end-to-side suture technique.Results The total ischeamic time of the graft was shortened to 30 min,and the 7-day survival rate of the recipient was increased to 97% by using the technique.Conclusions The development of cervical heart transplantation model in mice was a new,simple and useful technique.

关 键 词：颈部心脏移植 小鼠 动物模型 

分 类 号：R654.2[医药卫生—外科学]