左炔诺孕酮宫内缓释系统治疗子宫腺肌病80例临床分析  

The clinical analysis of levonorgestrel-releasing intrauterine system in eighty patients with adenomyosis

作　　者：张霞[1] 

机构地区：[1]河南省商丘市第一人民医院妇产科,476100

出　　处：《中国医师进修杂志》2013年第33期4-6,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的 探讨左炔诺孕酮宫内缓释系统（LNG-IUS）治疗子宫腺肌病的临床效果.方法 选择子宫腺肌病患者80例,均给予LNG-IUS治疗,观察治疗前及治疗后3、6、12个月的痛经程度、月经量、子宫体积、子宫内膜厚度、血红蛋白、激素变化及不良反应发生情况.结果 与治疗前比较,治疗后3、6、12个月月经量随时间延长而明显减少[（52.4±8.4）％、（22.6±9.8）％、（14.8±8.6）％比（100.0±0.0）％],痛经评分逐渐降低[（1.2±0.5）、（0.8±0.4）、（0.3±0.2）分比（2.4±0.6）分],血红蛋白逐渐上升[（104.4±11.4）、（109.2±12.6）、（118.8±13.4） g/L比（88.6±16.5） g/L],子宫内膜厚度逐渐变薄[（6.3±1.4）、（3.6±0.8）、（1.8±0.5） mm比（9.2±2.8）mm],子宫体积逐渐缩小[（156.8 ±56.8）、（142.4±48.9）、（126.6±36.5） cm3比（172.6±62.5） cm3],差异均有统计学意义（P＜0.05）.治疗后3、6、12个月卵泡刺激素、黄体生成素及雌二醇与治疗前比较差异无统计学意义（P＞0.05）;与治疗前比较,治疗后3、6、12个月癌抗原125随时间延长而逐渐下降[（34.6±11.6）、（16.6±9.8）、（11.7±6.4） kU/L比（62.4±24.3） kU/L],差异均有统计学意义（P＜0.05）.结论 LNG-IUS治疗子宫腺肌病疗效确切,对卵巢功能影响小,值得在临床中推广应用.Objective To investigate the chnical effect of levonorgestrel-releasing intrauterine system（LNG-IUS） in patients with adenomyosis.Methods A total of eighty patients with adenomyosis were enrolled and underwent LNG-IUS insertion.The degree of dysmenorrhea,amount of menorrhea,size of the uterus,endometrial thickness,hemoglobin as well as hormonal changes and adverse reaction before treatment and after treatment for 3,6,12 months were compared.Results After treatment for3,6,12months,the amount of menorrhea was reduced [（52.4 ± 8.4）％,（22.6 ± 9.8）％,（14.8 ± 8.6）％ vs.（100.0 ±0.0）％],the scores of dysmenorrhea was reduced [（1.2 ± 0.5）,（0.8 ± 0.4）,（0.3 ± 0.2） scores vs.（2.4 ±0.6） scores],the level of hemoglobin was increased [（104.4 ± 11.4）,（109.2 ± 12.6）,（118.8 ± 13.4） g/L vs.（88.6 ± 16.5） g/L],the endometrial thickness was thinner [（6.3 ± 1.4）,（3.6 ± 0.8）,（1.8 ± 0.5） mm vs.（9.2 ± 2.8） mm],the size of the uterus was reduced [（156.8 ± 56.8）,（142.4 ± 48.9）,（126.6 ± 36.5）cm3 vs.（172.6 ± 62.5） cm3],there was significant difference compared with that before treatment （P ＜ 0.05）.After treatment for 3,6,12 months,the levels of folhcle-stimulating hormone,luteinizing hormone and estradiol had no significant difference compared with those before treatment （P ＞ 0.05）.After treatment for 3,6,12 months,the level of cancer antigen 125 was significantly reduced compared with that before treatment [（34.6 ± 11.6）,（16.6 ± 9.8）,（11.7 ± 6.4） kU/L vs.（62.4 ± 24.3） kU/L].Conclusiom The LNG-IUS has exact therapeutic effect in treatment of adenomyosis,and has little influence on ovarian function.It is worth of using in clinic.

关 键 词：左炔诺孕酮 子宫腺肌病 临床分析 

分 类 号：R711.71[医药卫生—妇产科学]