无创呼吸机对阻塞性睡眠呼吸暂停低通气综合征患者血清炎症因子水平的影响及疗效观察  

Influence and curative observation of noninvasive ventilator on serum inflammatory factor level of obstructive sleep apnea hypopnea syndrome patients

作　　者：夏态军[1,2] 

机构地区：[1]浙江省舟山医院 [2]温州医科大学附属舟山医院定海院区急诊科,浙江舟山316000

出　　处：《中国医药导报》2013年第34期51-53,共3页China Medical Herald

摘　　要：目的探讨无创呼吸机对阻塞性睡眠呼吸暂停低通气综合征（OSAHS）对患者血清炎症因子的影响及疗效观察。方法选择2010年1月。2013年1月浙江省舟山医院定海院区70例OSAHS患者，将其随机分为治疗组和对照组。两组患者予以控制血压、血脂，健康宣教和运动减肥等常规内科治疗。治疗组加用无创呼吸机治疗，疗程4周。观察两组患者治疗前后血清白介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）浓度变化。并观察治疗效果。结果两组患者治疗后呼吸暂停低通气次数（AHI）、最长呼吸暂停时间[（43．08±12．73）次／h、（25．63±6．12）次／n、（43．66±10．74）s、（21．53±6．01）s]均较治疗前[（60．12±15．72）次/h、（59．17±15．18）次／n、（50．42±11．33）s、（50．63±11．67）s]减少（t=2．87、2．35、3．47、3．54，P〈0．05或P〈0．01），且治疗组的减少幅度大于对照组（t=2．34、2．42，P〈0．05），而两组患者治疗后最低血氧饱和度（LSpO2）、血氧饱和度（MSp02）[（70．63±10．72）％、（88．79±7．13）％、（86．84±7．11）％、（91．47±6．10）％]均较治疗前[（60．54±7．13）％、（60．87±8．64）％、（81．37±6．14）％、（80．79±6．92）％1升高（t=2．41、2．11、2．84、2．19，P〈0．05或P〈0．01），且治疗组升高幅度明显大于对照组（t=2．41、2．10，P〈0．05）。两组患者治疗后血清细胞因子IL-6、TNF—α浓度[（45．86±10．76）、（29．63±7．70）、（64．54±16．87）、（45．63±12．21）ng／L]均较治疗前[（52．18±11．72）、（51．07±11．09）、（85．37±17．13）、（84．71±16．89）ng／L]降低（t=2．14、2．32、2．91、3．16，P〈0．05或P〈0．01），且治疗组降低的幅度大于对照组（t=2．44、2．31，P〈0．05）。结论无创呼吸机治疗OSAHS取得良好治疗效果，在改善睡眠监测数据的同时�Objective To discuss the influence and curative observation of noninvasive ventilator on serum inflammatory factor level of obstructive sleep apnea hypopnea syndrome （OSAHS） patients. Methods 70 cases of OSAHS patients from January 2010 To January 2013 collected by Dinghai Branch of Zhoushan Hospital of Zhejiang Province were divided into treatment group and control group at random. The patients in two groups were given the routine internal medicine treatment, including blood pressure and blood fat control, healthy education, the movement to lose weight and etc. The patients in treatment group were given medical treatment of noninvasive ventilator for 4 weeks additionally. The concentration change of serum interleukin-6 （IL-6） and tumor necrosis factor-α （TNF-α） of patients in two groups were observed before and after medical treatment, as well as the curative effect. Results After the medical treatment, the AHI and the longest apnea time of patients in two groups [（43.08±12.73） times/h, （25.63±6.12） times/h, （43.66±10.74） s, （21.53±6.01） s] were declined than before [（60.12± 15.72） times/h, （59.17±15.18） times/h, （50.42±11.33） s, （50.63±11.67） s] （t = 2.87, 2.35, 3.47, 3.54, P 〈 0.05 or P 〈 0.01）, and the declining rate in treatment group was much higher than that in control group （t = 2.34, 2.42, P 〈 0.05）. LSpO2 and MSpO2 of patients in two groups [（70.63±10.72）%, （88.79±7.13）%, （86.84±7.11）%, （91.47±6.10）%] were rose than before [（60.54±7.13）%, （60.87±8.64）%, （81.37±6.14）%, （80.79±6.92）%] （t = 2.41, 2.11, 2.84, 2.19, P 〈 0.05 or P 〈 0.01）, and the rising rate in treatment group was much higher than that in control group after the medical treatment （t = 2.41, 2.10, P 〈 0.05）. The concentration of serum cytokine IL-6 and TNF-c± of patients in two groups after treatment [（45.86±10.76）, （29.63± 7.70）, （64.54±16.87）, （45.63±12.21） ng/L] were declined than before treatment [

关 键 词：无创呼吸机 阻塞性睡眠呼吸暂停低通气综合征 炎症因子 

分 类 号：R563.1[医药卫生—呼吸系统]