对乙酰氨基酚的合成条件正交设计优化  

Synthesis of Paracetamol and Process Optimization

作　　者：祝世发[1] 唐辉[1] 赵文斌[1] 

机构地区：[1]石河子大学药学院,石河子832002

出　　处：《数理医药学杂志》2013年第6期703-704,共2页Journal of Mathematical Medicine

摘　　要：目的:考察对乙酰氨基酚合成工艺的条件,反应条件涉及温度、物料比、反应时间、及反应溶剂等各条件对反应收率的影响。方法:通过正交设计寻找最佳工艺,运用熔点测定仪、元素分析、IR等手段进行确认。结果:棉酚与磺胺衍生物合成的最佳工艺为反应温度45℃,反应时间为1h,反应溶剂为无水乙醇,物料比为1:2.5。结论:生成的衍生物有较强的脂溶性,在优化工艺下进行反应产量较高,为乙酰氨基酚衍生物合成提供了较好的方法。Objective： In this paper,a method of studying paracetamol synthesis technology of conditions, reaction conditions concerned with reaction temperation, ratio of reactants, reaction time and sort of solvent. Methods： by orthogonal experimental design search for best process, use melting point apparatus , UV, IR, determination measure whether have the new material. By TLC monitor the extent of reactions. Results： paracetamol synthesis technology of best condition is reaction temperation 45~C, reaction time lh, sort of solvent is anhydrous ,and alcohol ratio of reactants 1：2.5. Conclusion： these derivatives have strong fat-- soluble, by orthogonal experimental design search for best process have high yield,and provide a good meth- od of studying p-acetaminophenol synthesis.

关 键 词：乙酰氨基酚 合成 工艺优化 

分 类 号：R284.2[医药卫生—中药学]