鸡毒支原体两种油佐剂灭活疫苗的安全与效力比较试验  

Safety and Potency Test of Mycoplasma Gallisepticum Inactivated Vaccines Made from Adjuvant Montanide ISA 775 VG and Marcol-52

作　　者：齐冬梅 赖月辉 穆光慧 敖艳华 李嘉爱 

机构地区：[1]广东永顺生物制药股份有限公司,广东广州511356

出　　处：《广东畜牧兽医科技》2013年第6期27-29,共3页Guangdong Journal of Animal and Veterinary Science

摘　　要：本研究选择ISA 775 VG佐剂和Marcol-52白油佐剂制备鸡毒支原体灭活疫苗(R株),对其物理性状、安全性和效力进行比较试验。结果表明:两种佐剂制备的疫苗物理性状良好;ISA 775 VG佐剂疫苗粘度比Marcol-52白油佐剂疫苗低;Marcol-52白油佐剂疫苗安全性优于ISA 775 VG佐剂疫苗;气囊损伤保护率ISA 775 VG佐剂疫苗为100%,Marcol-52白油佐剂疫苗组为79.81%。In this study, we compared the properties, safety and potency of Mycoplasma gallisepticum inactivated vaccines made from adjuvant Montanide ISA 775 VG and Marcoi-52 respectively. As results show, both vaccines were of good properties, ISA 775 VG adjuvant vaccine had lower viscosity than the Marcol-52 one. On the other hand, Marcol-52 adjuvant vaccine was safer. 100% and 79.81% protective effects of air sacs damages were observed in the ISA 775 VG group and Marcol-52 group while all the 12 chickens in control group were morbidity.

关 键 词：鸡毒支原体灭活疫苗 ISA 775 VG佐剂 Marcol-52白油佐剂 安全试验 效力试验 

分 类 号：S858.31[农业科学—临床兽医学]